Sökning: "protein modification"
Visar resultat 16 - 20 av 330 avhandlingar innehållade orden protein modification.
16. Catalysis and Site-Specific Modification of Glutathione Transferases Enabled by Rational Design
Sammanfattning : This thesis describes the rational design of a novel enzyme, a thiolester hydrolase, derived from human glutathione transferase (GST) A1-1 by the introduction of a single histidine residue. The first section of the thesis describes the design and the determination of the reaction mechanism. LÄS MER
17. Structure-Function Relationships of Pi Class Glutathione Transferase Studied by Protein Engineering
Sammanfattning : The glutathione transferases (GSTs) represent a superfamily of dimeric proteins involved in cellular detoxication by catalyzing the nucleophilic addition of the reduced glutathione (GSH) to the hydrophobic electrophiles. The present work focuses on the functional role of the conserved structures of GSTP1-1. LÄS MER
18. Bioinformatic methods in protein characterization
Sammanfattning : Bioinformatics is an emerging interdisciplinary research field in which mathematics. computer science and biology meet. In this thesis. bioinformatic methods for analysis of functional and structural properties among proteins will be presented. LÄS MER
19. Studies of calcium binding proteins 1 and 2 and protein kinase CK2
Sammanfattning : The endoplasmic reticulum (ER) is a major intracellular compartment of eukaryotic cells and is the site of the synthesis and post-translational modification of both secretory and membrane glycoproteins. Upon cell rupture vesicles of several kinds are formed from cell membranes, mainly derived from ER and are called microsomes. LÄS MER
20. Purine and Pyrazolopyrimidine Derivatives: Design and Synthesis of Chemical Tools for Biological Applications
Sammanfattning : Purines can be found in a multitude of naturally occurring compounds with a range of functions. This thesis describes the design and synthesis of purines and structurally related pyrazolopyrimidine derivatives intended for biological applications. LÄS MER