Sökning: "microsomes"
Visar resultat 1 - 5 av 55 avhandlingar innehållade ordet microsomes.
1. Metabolite Profiling of Drugs using Mass Spectrometry : Identification of analytical targets for doping control and improvements of the metabolite search process
Sammanfattning : Doping is defined as the use of prohibited substances or methods by the World Anti-Doping Agency and the aim with doping control analysis is to detect the use of these illicit substances or methods. Substances that are prohibited in human or equine sports have either a positive or negative impact on the performance. LÄS MER
2. Fatty acid hydroxylation in rat kidney and liver microsomes
Sammanfattning : .... LÄS MER
3. Cytochromes P-450 in biosynthesis of bile acids and metabolism of vitamin D3 : studies on cytochrome P-450 isozymes in rat liver microsomes
Sammanfattning : .... LÄS MER
4. Proteomics-informed analysis of drug disposition in the human liver and small intestine
Sammanfattning : Orally administered drugs are absorbed in the intestine and generally metabolized in the liver. Therefore, understanding factors determining drug distribution and elimination in these tissues is important. LÄS MER
5. Drug transport and metabolism in in vitro models of the human intestine : By Shamsi D. Raeissi
Sammanfattning : The objective of this thesis was to study the mechanisms of drug transport and metabolism in two different in vitro models of the human intestine: monolayers of human intestinal epithelial cell lines and intestinal microsomes. The first part of the thesis shows that Caco-2 cell monolayers are a good model for mechanistic studies of drug transport. LÄS MER