Sökning: "parent-of-origin effects"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden parent-of-origin effects.

  1. 1. Fetal programming and parent-of-origin effects of type 2 diabetes and insulin secretion

    Författare :Gad Hatem; diabetes och endokrinologi Genomik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Type 2 Diabetes; fetal programming; parent-of-origin effects; transcriptopmics;

    Sammanfattning : Abstract Type 2 diabetes mellitus (T2DM) is a heterogeneous and a complex disease defined by hyperglycemia. Thepancreas and its islets are central for glucose homeostasis and healthy adipose tissue. In turn, lipid levels in the bloodare crucial for glucose level stability. LÄS MER

  3. 2. Genetic dissection of multifactorial disease models in the rat

    Författare :Hong Jiao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type 2 daibetes; Goto-Kakizaki rat; linkage analysis; quantitative trait locus; gene-gene interaction; mitochondrial sequence; parent-of-origin;

    Sammanfattning : Type 2 diabetes (T2D) is characterized by two apparently distinct pathophysiologic defects - insulin resistance and a failure of the pancreatic Beta-cells to compensate for this resistance by appropriately increasing insulin secretion. There is strong evidence for an important role of genetics in both of these components. LÄS MER

  4. 3. Growth and Behaviour : Epigenetic and Genetic Factors Involved in Hybrid Dysgenesis

    Författare :Wei Shi; Reinald Fundele; Diethard Tautz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Interspecies hybridization; hybrid dysgenesis effect; speciation; genomic imprinting; epigenetics; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : In mammals, the most frequently observed hybrid dysgenesis effects are growth disturbances and male sterility. Profound defects in placental development have been described and our work on hybrids in genus Mus has demonstrated putative hybrid dysgenesis effects that lead to defects in lipid homeostasis and maternal behavior. LÄS MER

  5. 4. Genetic studies in familial non-BRCA breast cancer

    Författare :Camilla Wendt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Family history is an important risk factor for breast cancer, the presence of breast cancer in a first degree relative in general nearly doubles the risk and the risk increases with the number of affected relatives. Pathogenic mutations in BRCA1, BRCA2 and other high- and moderate risk-genes account for 25% of the familial risk for breast cancer. LÄS MER

  7. 5. Genetic and epigenetic factors shaping the transcriptome in multiple sclerosis and its animal model

    Författare :Petra Bergman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple Sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. Susceptibility to develop MS is determined by both genetic and environmental factors. The epigenome resides in the interface of genetic and environmental factors thereby shaping the transcriptome. LÄS MER