Sökning: "Reinald Fundele"

Hittade 4 avhandlingar innehållade orden Reinald Fundele.

1. 1. Epigenetic Regulation of Higher Order Chromatin Conformations and Gene Transcription

   Författare :Anita Göndör; Reinald Fundele; Thomas Graf; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Genomic imprinting; Chromatin; Epigenetics; Cancer; Developmental biology; Utvecklingsbiologi;

   Sammanfattning : Epigenetic states constitute heritable features of the chromatin to regulate when, where and how genes are expressed in the developing conceptus. A special case of epigenetic regulation, genomic imprinting, is defined as parent of origin-dependent monoallelic expression. LÄS MER

3. 2. Growth and Behaviour : Epigenetic and Genetic Factors Involved in Hybrid Dysgenesis

   Författare :Wei Shi; Reinald Fundele; Diethard Tautz; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Interspecies hybridization; hybrid dysgenesis effect; speciation; genomic imprinting; epigenetics; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

   Sammanfattning : In mammals, the most frequently observed hybrid dysgenesis effects are growth disturbances and male sterility. Profound defects in placental development have been described and our work on hybrids in genus Mus has demonstrated putative hybrid dysgenesis effects that lead to defects in lipid homeostasis and maternal behavior. LÄS MER

4. 3. New Functions for Old Genes in the Mouse Placenta

   Författare :Umashankar Singh; Reinald Fundele; Anne C Ferguson-Smith; Uppsala universitet; []
   Nyckelord :Developmental biology; hybrid dysgenesis effects; placental hyperplasia; functional screening; giant cell; glycogen cell; Utvecklingsbiologi;

   Sammanfattning : Different species are separated by pre-zygotic reproductive barriers which impede gene flow between them. Rarely, when pre-zygotic barriers break down, interspecific hybrids are produced that display abnormal phenotypes, collectively called hybrid dysgenesis effects. LÄS MER

5. 4. Molecular Mechanisms Underlying Abnormal Placentation in the Mouse

   Författare :Yang Yu; Reinald H. Fundele; Rolf Ohlsson; J. GRAHAM BURTON; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; IUGR; Placental phenotype; Placental hyperplasia; Diabetes; IHPD; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

   Sammanfattning : Placental development can be disturbed by various factors, such as mutation of specific genes or maternal diabetes. Our previous work on interspecies hybrid placental dysplasia (IHPD) and two additional models of placental hyperplasia, cloned mice and Esx1 mutants, showed that many genes are deregulated in placental dysplasia. LÄS MER