Sökning: "paracellular permeability"

Visar resultat 16 - 20 av 28 avhandlingar innehållade orden paracellular permeability.

  1. 16. Pathogenesis of an emerging pathogen : Crimean-Congo hemorrhagic fever virus

    Författare :Anne-Marie Connolly-Andersen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epithelial cells represent the first barrier to viral infection and the site of viral entry and release is often intimately connected with viral spread and pathogenesis. The plasma membrane of epithelial cells is polarized into an apical and basolateral domain separated by tight junctions (TJs). LÄS MER

  3. 17. The intestinal epithelium of salmonids : transepithelial transport, barrier function and bacterial interactions

    Författare :Fredrik Jutfelt; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Epithelial barrier function; smoltification; cortisol; osmoregulation; Aeromonas salmonicida; Atlantic salmon; rainbow trout; bacterial translocation; intestine; Ussing chamber; vegetable lipids;

    Sammanfattning : The salmonid intestinal epithelium is important for growth and health of the fish. The epithelium is exposed to a multitude of internal and external factors that can influence its function. LÄS MER

  4. 18. The role of angiomotin in endothelial cell motility and cell-cell junction formation

    Författare :Anders Bratt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Angiogenesis; cancer; angiostatin; angiomotin; cell motility cell-cell junction; tight junction; adherens junction;

    Sammanfattning : Clinical as well as pre-clinical data show that tumor growth can be restrained by inhibiting angiogenesis. We have been investigating the mechanism of action of angiostatin, an inhibitor of angiogenesis, in order to design novel therapies against cancer. LÄS MER

  5. 19. Drug transport and metabolism in in vitro models of the human intestine : By Shamsi D. Raeissi

    Författare :Shamsi D. Raeissi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Sammanfattning : The objective of this thesis was to study the mechanisms of drug transport and metabolism in two different in vitro models of the human intestine: monolayers of human intestinal epithelial cell lines and intestinal microsomes. The first part of the thesis shows that Caco-2 cell monolayers are a good model for mechanistic studies of drug transport. LÄS MER

  7. 20. Experimental studies on Damage Control Surgery and Intraabdominal Hypertension

    Författare :Pia Olofsson; Thore Wikström; Kenth Johansson; Sten Lennquist; Fikri M Abu-Zidan; Louis Riddez; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Damage control surgery (DCS) offers an alternative to the traditional surgical management of complex or multiple injuries in critically injured patients. If a patient survives the initial phase of DCS, complications may occur, one of these being intraabdominal hypertension (IAH) and it´s potential development into the abdominal compartment syndrome. LÄS MER