Sökning: "paracellular permeability"

Visar resultat 6 - 10 av 28 avhandlingar innehållade orden paracellular permeability.

  1. 6. Gut peptides in gastrointestinal motility and mucosal permeability

    Författare :Md. Abdul Halim; Webb Dominic-Luc; Per M Hellström; Lars Fändriks; Uppsala universitet; []
    Nyckelord :Gut regulatory peptides; Neuropeptides; Gastrointestinal mucosal permeability; Gastrointestinal motility; GLP-1; NPS; ROSE-010;

    Sammanfattning : Gut regulatory peptides, such as neuropeptides and incretins, play important roles in hunger, satiety and gastrointestinal motility, and possibly mucosal permeability. Many peptides secreted by myenteric nerves that regulate motor control are also produced in mucosal epithelial cells. LÄS MER

  3. 7. ATP-Binding Cassette Efflux Transporters and Passive Membrane Permeability in Drug Absorption and Disposition

    Författare :Pär Matsson; Per Artursson; Ulf Norinder; Peter Swaan; Uppsala universitet; []
    Nyckelord :Pharmaceutics; ATP-binding cassette; ABC transporter; P-gp; P-glycoprotein; ABCB1; BCRP; Breast cancer resistance protein; ABCG2; MRP2; Multidrug-resistance associated protein 2; ABCC2; Membrane permeability; Drug transport; Active transport; Passive diffusion; Multivariate data analysis; PLS; OPLS; QSAR; Galenisk farmaci;

    Sammanfattning : Transport into and across the cells of the human body is a prerequisite for the pharmacological action of drugs. Passive membrane permeability and active transport mechanisms are major determinants of the intestinal absorption of drugs, as well as of the distribution to target tissues and the subsequent metabolism and excretion from the body. LÄS MER

  4. 8. Evaluation of polysucrose 15000 as a marker of intestinal permeability

    Författare :Hans Öman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Polysucrose Permeability Intestinal Absorption Cell Memhrane Permeahility Molecular WeightMacromolecular systems Biological Markers Biological Transport Crohn Disease Arthritis; RheumatoidAnti-lnflammatory Agents; Non-Steroidal Chromium Radioisotop;

    Sammanfattning : Polysucrose (PS) is a synthetic copolymer of sucrose and epichlorohydrin, which can be produced in a variety of molecular sizes. The aim of the study was to evaluate the functionality of PS 15000, mean mol wt 14700, as a marker for intestinal permeability to macro molecules. LÄS MER

  5. 9. Luminal Hypotonicity and Duodenal Functions : An Experimental Study in the Rat

    Författare :Liselotte Pihl; Olof Nylander; Gunnar Flemström; Mats Jodal; Uppsala universitet; []
    Nyckelord :Physiology; luminal alkalinization; mucosal permeability; osmolality; cyclooxygenase-2; rat; duodenum; jejunum; motility; enteric nervous system; Fysiologi;

    Sammanfattning : After drinking water, the fluid quickly leaves the stomach thereby creating a hypotonic luminal environment in the duodenum. This in turn constitutes a potential threat to the integrity of the duodenal epithelium. It therefore seems highly likely that luminal hypotonicity activates physiological mechanisms that aim to increase luminal osmolality. LÄS MER

  7. 10. Regulation of Duodenal Mucosal Barrier Function and Motility : The Impact of Melatonin

    Författare :Anna Sommansson; Markus Sjöblom; Olof Nylander; Oliver Bachmann; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 51Cr-EDTA; bicarbonate secretion; duodenum; enteric nervous system; enterochromaffin cell; ethanol; hexamethonium; in vivo; mecamylamine; motility; mucosal permeability; parecoxib; rat; Physiology; Fysiologi;

    Sammanfattning : The duodenal mucosa is regularly exposed to acid, digestive enzymes and ingested noxious agents. It is thus critical to maintain a protective barrier to prevent the development of mucosal injury and inflammation, which are often observed in situations when barrier function is impaired. LÄS MER