Sökning: "pancreatic beta-cells"

Visar resultat 6 - 10 av 105 avhandlingar innehållade orden pancreatic beta-cells.

  1. 6. Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function

    Författare :Magdalena Mazur; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreas development; beta cells; insulin; MafA; MafB; Mitf; diabetes;

    Sammanfattning : Diabetes - the imbalance in glucose homeostasis is partially caused by loss or dysfunction of pancreatic insulin producing β cells or development of insulin resistance. In Type 1 diabetes β cells are destroyed in the process of an autoimmune attack, whereas in Type 2 diabetes, islets produce insufficient amounts of insulin or the insulin cannot be used adequately. LÄS MER

  3. 7. From the pancreatic beta cell to the endothelium:Pathophysiological aspects of Type 2 Diabetes

    Författare :Marloes Dekker Nitert; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sekretion; diabetologi; diabetology; insulin secretion; beta cells; glucose tolerance; insulin receptors; IGF-I receptors; endothelial cells; Endokrinologi; Type 2 Diabetes; secreting systems; Endocrinology;

    Sammanfattning : The incidence of Diabetes Mellitus increases globally in epidemic proportions. Type 2 Diabetes is the most prevalent form of Diabetes, comprising 90% of the patients. In Type 2 Diabetes, two processes contribute to the development of the disease: insufficient insulin secretion from the pancreatic ?-cell and insulin resistance of the target organs. LÄS MER

  4. 8. Components controlling vesicle trafficking and regulated exocytosis in pancreatic beta-cells

    Författare :Slavena Andrea Mandic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Regulated exocytosis is a sophisticated, well-organized and conserved multistage process underlying release of both neurotransmitters and hormones. Exocytosis is mediated by SNARE proteins that act at the center stage by forming a SNARE complex with the intrinsic capability to execute membrane fusion. LÄS MER

  5. 9. Interaction between pancreatic cancer and beta cells : intraislet significance of islet amyloid polypeptide

    Författare :Feng Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :pancreatic cancer; pancreatic islet; insulin; IAPP; somatostatin; glucagon;

    Sammanfattning : Introduction: Mutual influences have been found between exocrine pancreatic cancer and the endocrine pancreatic islets. In laboratory animals, induction and growth of pancreatic cancer are affected by the endocrine pancreas. Conversely, abnormalities of the endocrine pancreas are frequently seen in mammals with pancreatic cancer. LÄS MER

  7. 10. Control of metabolism and hormone secretion from pancreatic alpha and beta cells

    Författare :Jelena Stamenkovic; Diabetes - molekylär metabolism; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CLOCK genes; insulin; glucagon; metabolites; mitochondria; knock out;

    Sammanfattning : Type 2 Diabetes (T2D) is a multifactorial disease, which has made it difficult to resolve its pathophysiology. We investigated processes that could contribute to the development of T2D. LÄS MER