Sökning: "orphan proteins"
Visar resultat 1 - 5 av 27 avhandlingar innehållade orden orphan proteins.
1. Orphan Genes Bioinformatics : Identification and properties of de novo created genes
Sammanfattning : Even today, many genes are without any known homolog. These "orphans" are found in all species, from Viruses to Prokaryotes and Eukaryotes. For a portion of these genes, we might simply not have enough data to find homologs yet. LÄS MER
2. Intrinsic disorder and tandem repeats - match made in evolution : Computational studies of molecular evolution
Sammanfattning : Proteins are both the building blocks and workers of the cell, carrying out most of the important functions. For a long time, their structure has been regarded as the primary factor for their function, but intrinsically disordered proteins demonstrate an alternative to this paradigm. LÄS MER
3. Studies on the atypical orphan receptor SHP
Sammanfattning : Nuclear receptors (NRs) comprise the largest family of transcription factors in eukaryotes and play critical roles in nearly every aspect of vertebrate development and adult physiology. In general, they function as transcriptional regulators that when bound to DNA either activate or suppress target gene expression. LÄS MER
4. Molecular mechanisms of transcriptional repression by the orphan receptor SHP
Sammanfattning : SHP (Small Heterodimer Partner) is an atypical orphan member of the mammalian nuclear receptor family that consists of only a putative ligand-binding domain and thus cannot bind DNA. The aim of this thesis was to investigate the molecular mechanisms of the transcriptionally inhibitory effect of SHP. LÄS MER
5. Functional studies on the orphan receptor Nurr1 and related retinoid receptors
Sammanfattning : Nuclear receptors (NRs) constitute a large family of ligand-inducible transcription factors which includes receptors for steroid hormones, retinoids (vitamin A derivatives), vitamin D an d thyroid hormone. The family also includes a large number of structurally related proteins that lack identified ligands and are therefore refered to as orphan receptors. LÄS MER