Sökning: "oligosaccharide synthesis"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden oligosaccharide synthesis.

1. 1. Solid-phase glycoconjugate synthesis : on-resin analysis with gel-phase ¹9F NMR spectroscopy

   Författare :Mickael Mogemark; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Solid-phase synthesis; protective groups; linkers; monitoring; gel-phase; 19F NMR spectroscopy; carbohydrates; oligosaccharides; glycopeptides; Organisk kemi; Organic chemistry; Organisk kemi;

   Sammanfattning : An efficient and versatile non-destructive method to analyze the progress of solid-phase glycoconjugate synthesis with gel-phase 19F NMR spectroscopy is described. The method relies on use of fluorinated linkers and building blocks carrying fluorinated protective groups. LÄS MER

3. 2. Synthesis of Orthogonally Functionalized Oligosaccharides for Self-assembled Monolayers and as Multimodal Tools in Chemical Biology

   Författare :Timmy Fyrner; Peter Konradsson; Stefan Svensson; Bo Liedberg; Ulf Ellervik; Linköpings universitet; []
   Nyckelord :Oligosaccharide synthesis; glycosylation; thioglycosides; orthogonally protected; oligo lactosides ; spacer molecule; heterobifunctional; surface plasmon resonance; lipid anchor; self-assembled monolayers; glyconanoparticles;

   Sammanfattning : This thesis covers different topics in the field of synthetic organic chemistry combined with the field of surface science and glycobiology.First, the text presents a series of orthogonally protected oligosaccharides (tri-, penta-, and heptasaccharides) of varying length and structures, which are synthesized with the aim of developing novel heterobifunctional biocompatible cross-linkers. LÄS MER

4. 3. Synthesis of Bacterial Oligosaccharides from N. meningitidis and Mechanistic Details of Stereoselective Glycosylations Using a Novel Bicyclic Donor

   Författare :Johan Olsson; Stefan Oscarson; Jeroen Codée; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; oligosaccharide synthesis; heptose; thioglycoside; glycosylation; Neisseria meningitidis; 2; 3-oxazolidinone; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : This thesis includes two parts. The first part, comprising Chapters 3, 4 and 5, describes the synthesis of bacterial oligosaccharides. In Chapters 3 and 4, the synthesis of branched and phosphorylated oligosaccharide structures corresponding to inner core epitopes of the lipopolysaccharide (LPS) of the Gram-negative bacteria N. LÄS MER

5. 4. Synthesis of some oligosaccharide fragments of biological and chemical interest using thioglycosides

   Författare :Christer Hällgren; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

   Sammanfattning : This thesis describes the synthesis of oligosaccharide derivatives corresponding to the repeating unit of the O-antigen from two different bacteria, Shigella dysenteriae type 1 and Salmonella thompson serogroup Ci, and fragments thereof. Synthesis of a decasaccharide of chemical interest for studying carbohydrate dynamics in elongated molecules is also described. LÄS MER

7. 5. Synthesis of inositol phosphoglycans and analogues thereof

   Författare :Katinka Ruda; JS Brimacombe; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

   Sammanfattning : This thesis describes the synthesis of inositol phosphoglycans (IPG) corresponding to glycosyl-phosphatidylinositol (GPI) anchors found on the cell surface of the parasite Leishmania. Synthesis of an IPG which is a putative second messenger for insulin, and of analogues thereof is also discussed. LÄS MER