Sökning: "enantiomeric excess analysis"

Hittade 4 avhandlingar innehållade orden enantiomeric excess analysis.

  1. 1. Enzyme selectivity as a tool in analytical chemistry

    Författare :Anders Hamberg; Karl Hult; Harry Brumer; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; substrate specificity; competing substrates; enantiomeric excess analysis; library screening; ladder sequencing; carboxypeptidase Y; 2-pyridylmethylamine; MALDI; Candia antarctica lipase B; pig liver esterase; horse liver alcohol dehydrogenase; acylated cyanohydrins; Biochemistry; Biokemi;

    Sammanfattning : Enzymes are useful tools as specific analytical reagents. Two different analysis methods were developed for use in the separate fields of protein science and organic synthesis. Both methods rely on the substrate specificity of enzymes. Enzyme catalysis and substrate specificity is described and put in context with each of the two developed methods. LÄS MER

  3. 2. Organocatalytic Acylation for the Kinetic Resolution of Secondary Aryl Alcohols : Synthetic Applications and Mechanistic Studies

    Författare :Laura Mesas Sánchez; Peter Dinér; Pavel Kočovský; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; kinetic resolution; organocatalysis; secondary alcohols; reaction progress kinetic analysis; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

    Sammanfattning : The research described in this thesis focuses on the catalytic acylative kinetic resolution (KR) of aromatic secondary alcohols, using a planar-chiral 4-(dimethylamino)pyridine (DMAP) organocatalyst.In the first part of this thesis, the substrate scope of the above mentioned process was expanded to aromatic secondary alcohols that contain an extra functional group in the alkyl moiety, such as 1,2-azido alcohols, 2-hydroxy-2-aryl-ethylphosphonates and 2-hydroxy-2-aryl esters. LÄS MER

  4. 3. Serine Hydrolase Selectivity : Kinetics and applications in organic and analytical chemistry

    Författare :Anders Hamberg; Karl Hult; Dick Janssen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Candida antarctica lipase B; monoacylation of diols; kinetic resolution; thermodynamics in enzyme catalysis; enzyme engineering; Biochemistry; Biokemi;

    Sammanfattning : The substrate selectivities for different serine hydrolases were utilized in various applications, presented in papers I-VI. The articles are discussed in the thesis in view of the kinetics of the enzyme catalysis involved. LÄS MER

  5. 4. New Methods for Chiral Cyanohydrin Synthesis

    Författare :Erica Wingstrand; Christina Moberg; Benjamin List; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; acyl cyanides; asymmetric synthesis; biocatalysis; cyanide; cyanohydrins; dual activation; enzymes; high-throughput screening; Lewis acid; Lewis base; metal catalysis; minor enantiomer recycling; salen; titanium; Chemistry; Kemi;

    Sammanfattning : This thesis deals with method development in asymmetric catalysis and specifically syntheses of enantioenriched O-functionalized cyanohydrins. The first part describes the development of a method for the synthesis of O‑alkoxycarbonylated and O-acylated cyanohydrins. LÄS MER