Sökning: "nucleocapsid protein"

Visar resultat 6 - 10 av 24 avhandlingar innehållade orden nucleocapsid protein.

  1. 6. Assembly and entry mechanisms of Semliki Forest virus

    Författare :Bernd Uwe Barth; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Semliki Forest virus; virus assembly; protein oligomerization; virus budding;

    Sammanfattning : The genomes of enveloped viruses are packaged into a core or nucleocapsid (NC) which is surrounded by a lipid membrane with spike proteins. These viruses mature by budding at a membrane of the host cell, usually the plasma membrane (PM), and penetrate into new ones by a virus-host membrane fusion event. LÄS MER

  3. 7. Puumala hantavirus : immune responses and vaccines

    Författare :Cristina de Carvalho Nicacio; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hantavirus; Puumala virus; nucleocapsid protein; neutralizing antibodies; Fab fragment; combinatorial library; phage-display; IgA; cellular immunity; cross-protection; intranasal vaccination;

    Sammanfattning : Hantaviruses (family Bunyaviridae) is a group of closely related zoonotic rodent-borne viruses that are transmitted to humans through inhalation of infected rodent excreta. They cause hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS) with varying degree of severity depending on the causative virus. LÄS MER

  4. 8. SARS coronavirus : the role of accessory proteins and nitric oxide in the replication cycle

    Författare :Sara Åkerström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Severe acute respiratory syndrome coronavirus (SARS-CoV) caused the first pandemic of the 21st century. The etiological agent was identified as a novel coronavirus. Until then, human coronaviruses (HCoVs) had only been known to cause the common cold . Data indicated that the virus originated from animals. LÄS MER

  5. 9. Advanced molecular tools for diagnostic analyses of RNA and antibodies in situ and in solution

    Författare :Mengqi Wang; Ulf Landegren; Anders Ståhlberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Homogenous serological assay; PCR-based antibody detection; Proximity extension assay; SARS-CoV-2 antibody; Extracellular vesicles; Proximity barcoding assay; in situ superRCA; mutant transcript;

    Sammanfattning : Advanced molecular diagnostics uses in vitro biological assays to detect nucleic acids or proteins even in low concentrations across samples, allowing for the identification of biomarkers, monitoring the course of the disease over time, and selection of appropriate therapy. In this thesis, I focus on development and early applications of several molecular tools of expected value in research, and eventually also clinically. LÄS MER

  7. 10. Assembly of semliki forest and influenza A viruses

    Författare :Hongxing Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Semliki forest virus; influenza virus; virus budding.;

    Sammanfattning : Enveloped viruses contain an external lipid membrane with spikes surrounding their nucleocapsid (NC). The envelope is acquired at a late stage of virus assembly by budding of the NC through a virus-modified host membrane. LÄS MER