Sökning: "metyrapone"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet metyrapone.

  1. 1. Taste Hedonics and the Intake of Alcohol and Food

    Författare :Anna Söderpalm; Göteborgs universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Alcohol drinking; Adrenalectomy; Corticosterone; Cyanoketone; Food intake; Food restriction; GABA; Metyrapone; Taste reactivity; Benzodiazepine; Chlordiazepoxide; Cis Z -flupentixol; Diazepam; Flumazenil; Microinjections; Midazolam; Nucleus of the Solitary tract; Palatability; Parabrachial nucleus; Peduculopontine Tegmental Nucleus; Reward; 4th ventricle.;

    Sammanfattning : This thesis includes four papers based on animal experimental work. They analyze the way in which activation of a specific motivational state - hunger- modulates the rewarding actions of alcohol and taste palatability. LÄS MER

  3. 2. Allergen-induced late airways reaction in the pig : influence of endogenous and exogenous glucocorticoids

    Författare :Cecilia Fornhem; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ascaris suum; bronchial circulation; bronchial provocation test; budesonidecortisol; leukotrienes; eosinophil peroxidase; eosinophils; histamine; immunohistochemistry; metyrapone; minipig; myeloperoxidase; neutrophils; pig.;

    Sammanfattning : A novel model for studies of the allergen-induced late reaction in the lower airways was developed in the pig. The influence on late bronchial obstruction and granulocyte function of endogenous cortisol levels and treatment with the glucocorticoid budesonide (BUD) was evaluated. LÄS MER

  4. 3. Adrenal Bioactivation and Toxicity of 3-MeSO2-DDE, o,p´-DDD and DMBA Investigated in Tissue Slice Culture

    Författare :Örjan Lindhe; Jan Alexander; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; adrenal cortex; 3-MeSO2-DDE; o; p´-DDD; DMBA; bioactivation; binding; toxic; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Ecotoxicology; ekotoxikologi;

    Sammanfattning : I developed a precision-cut adrenal slice culture procedure to investigate cytochrome P450 (CYP) catalysed irreversible binding and adrenocorticolytic effects in human, rodent, and fish adrenal tissue, ex vivo. Autoradiography and radioluminography of exposed tissue slices showed that the potent adrenal toxicant 3-methylsulphonyl-2,2´-bis(4-chlorophenyl)-1,1´-dichloroethene (MeSO2-DDE) causes a selective metabolite binding in zona fasciculata (ZF), which is diminished by the CYP11B1 inhibitor metyrapone. LÄS MER

  5. 4. Improving maintenance treatment of heroin addiction : the role of buprenorphine

    Författare :Karl Johan Kakko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Heroin addiction is a condition with high morbidity and mortality. The discovery of Methadone Maintenance Treatment (MMT) by Dole and co-workers 1964 represented the first major advance in the treatment of this condition. Through the work of Gunne et al in Uppsala, MMT was implemented in Sweden already in 1966. LÄS MER

  7. 5. Modulation of the HPA axis alters the sensitivity of the cochlea to acoustic trauma

    Författare :Yeasmin Tahera; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HPA axis; corticosterone; glucocorticoid receptor; NFêB; spiral ganglion neurons; cochlea; acoustic trauma; paraventricular nucleus;

    Sammanfattning : The hypothalamic pituitary adrenal axis (HPA axis) regulates nearly all neuroendocrine responses of the body. An active HPA axis is crucial to maintaining homeostasis. An altered reactivity of the HPA axis can affect several physiological systems including the auditory system. LÄS MER