Sökning: "monoamine compounds"

Visar resultat 6 - 10 av 10 avhandlingar innehållade orden monoamine compounds.

1. 6. Amine oxidases in dental pulp : a study with special regard to a semicarbazide-sensitive amine oxidase with catalytic potency towards serotonin

   Författare :Astrid Norqvist-Sjöberg; Lars Oreland; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : The amine oxidizing capacity of piglet dental pulp tissue has been investigated. At least six separate enzyme activities could be distinguished:- a soluble semicarbazide-sensitive (SSAO) activity towards benzylamine, most likely to be derived from the content of blood plasma within the pulp tissue;- a soluble pulp tissue SSAO activity with most properties in common with the plasma enzyme, however with great efficiency not only regarding benzylamine but also tryptamine;- a tissue bound SSAO activity with activity towards benzylamine, tryptamine, tyramine and ß-phenylethylamine;- a tissue bound semicarbazide-sensitive activity towards serotonin (SSA0-5HT) (a combination of properties never reported before);- a mitochondrially bound and clorgyline-sensitive monoamine oxidase-A (MAO-A) activity with activity towards serotonin;- a mitochondrially bound and deprenyl-sensitive MAO-B activity with activity towards e. LÄS MER

3. 7. Genetic predisposition and risk factors for neurodegenerative diseases with special emphasis on Parkinson's disease and solvent-induced chronic toxic encephalopathy

   Författare :Ahmad Ahmadi; Margareta Warholm; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : The inter-individual variability in biotransformation, may lead to differences in activation and detoxification of both endogenous and exogenous compounds. Polymorphism studies in such genes were applied for Parkinson's disease (PD) and Chronic toxic encephalopathy (CTE), two diseases influenced by both genetic and enviromnental factors. LÄS MER

4. 8. In vitro cellular models for neurotoxicity studies : neurons derived from P19 cells

   Författare :Dina Popova; Jacobsson Stig O.P.; Anna Forsby; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurotoxicity; Neuronal cell culture; P19 cells; SH-SY5Y cells; βIII-tubulin; Methylmercury; Okadaic acid; Acrylamide; MDMA; Piperazine-derived designer drugs.;

   Sammanfattning : Humans are exposed to a variety of chemicals including environmental pollutants, cosmetics, food preservatives and drugs. Some of these substances might be harmful to the human body. LÄS MER

5. 9. Towards a novel treatment of Huntington’s disease

   Författare :Mouna Esmaeilzadeh; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The function of the human brain is based on complex interactions between billions of neurons. The brain function declines as a result of normal aging, but is also disturbed in neuropsychiatric and neurodegenerative disorders. LÄS MER

7. 10. Generation of cell diversity in the developing brainstem and its modeling in vitro

   Författare :Mariya Kozhevnikova; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The intersection of spatial and temporal patterning programs underlies the formation of neural cell type diversity in the developing central nervous system (CNS). Deciphering the molecular mechanisms regulating positional and temporal patterning provides a basic framework for how the developing brain can be functionally assembled, and the growing knowledge about these patterning mechanisms offer a powerful tool to effectively control the differentiation of pluripotent stem cells (PSCs) into different neuronal subtypes of clinical importance. LÄS MER