Sökning: "model-based estimation"

Visar resultat 16 - 20 av 141 avhandlingar innehållade orden model-based estimation.

1. 16. Model-Based Optimization of Clinical Trial Designs

   Författare :Camille Vong; Mats O. Karlsson; Andrew C. Hooker; Lena E. Friberg; Marylore Chenel; Oliver Sander; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

   Sammanfattning : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. LÄS MER

3. 17. Effective development of haptic devices using a model-based and simulation-driven design approach

   Författare :Aftab Ahmad; Kjell Andersson; Damien Chablat; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Haptic device; model-based design; design optimization;

   Sammanfattning : Virtual reality (VR)-based surgical simulators using haptic devices can increase the effectiveness of surgical training for surgeons when performing surgical procedures in hard tissues such as bones or teeth milling. The realism of virtual surgery through a surgical simulator depends largely on the precision and reliability of the haptic device, which reflects the interaction with the virtual model. LÄS MER

4. 18. Model-based optimization for individualized deep brain stimulation

   Författare :Rubén Cubo; Alexander Medvedev; Madeleine Lowery; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Neuromodulation; Deep Brain Stimulation; Inverse Problems; Optimization; Finite Element Methods; Elektroteknik med inriktning mot reglerteknik; Electrical Engineering with specialization in Automatic Control;

   Sammanfattning : Deep Brain Stimulation (DBS) is an established therapy that is predominantly  utilized in treating the symptoms of neurodegenerative diseases such as Parkinson's Disease and Essential Tremor, crippling diseases like Chronic Pain and Epilepsy, and psychiatric diseases such as Schizophrenia and Depression. Due to its invasive nature, DBS is considered as a last resort therapy. LÄS MER

5. 19. Model-based Analysis and Design of Atomic Layer Deposition Processes

   Författare :Anders Holmqvist; Avdelningen för kemiteknik; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Atomic layer deposition; Heterogeneous reaction kinetics; Limit-cycle dynamics; Parameter estimation; Multi-objective optimization; Dynamic optimization; Scale-up analysis;

   Sammanfattning : Atomic layer deposition (ALD) is a thin-film manufacturing process in which the growth surface is exposed to non-overlapping alternating injections of gas-phase chemical precursor species separated by intermediate purge periods to prevent gas-phase reactions. ALD is characterized by sequential self-terminating heterogeneous reactions between highly reactive gas-phase precursor species and surface-bound species which, when allowed sufficient conditions to reach saturation, results in highly conformal films, on both planar and topographically complex structures. LÄS MER

7. 20. On model based estimation of quality variables for paper manufacturing

   Författare :Jens Pettersson; KTH; []
   Nyckelord :;

   Sammanfattning : .... LÄS MER