Sökning: "Urban Hellman"
Visar resultat 1 - 5 av 6 avhandlingar innehållade orden Urban Hellman.
1. About hyaluronan in the hypertrophic heart : studies on coordinated regulation of extracellular matrix signalling
Sammanfattning : Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. LÄS MER
2. Sculpted through Time : Evolution and Function of Serine Proteases from the Mast Cell Chymase Locus
Sammanfattning : Immune cells like NK cells, T cells, neutrophils and mast cells store high amounts of granule serine proteases, graspases. Graspases are encoded from the mast cell chymase locus. The human locus holds four genes: α-chymase, cathepsin G, and granzymes H and B. In contrast, the mouse locus contains at least 14 genes. LÄS MER
3. Cardiac hypertrophy : transcription patterns, hypertrophic progression and extracellular signalling
Sammanfattning : Background: The aim of this thesis was to study transcription patterns and extracellular signalling of the hypertrophic heart to better understand the mechanisms initiating, controlling and maintaining cardiac hypertrophy.Cardiac hypertrophy is a risk factor for cardiovascular morbidity and mortality. LÄS MER
4. Cutting Edge – Cleavage Specificity and Biochemical Characterization of Mast Cell Serine Proteases
Sammanfattning : It is well established that mast cells (MC) are key players in airway pathologies such as allergic asthma, but they are also known to contribute to host defense and tissue remodeling. MC serine proteases are the major protein components of mast cell granules and accordingly, are most likely involved in many aspects of MC function. LÄS MER
5. Haematopoietic Serine Proteases : A Cleavage Specificity Analysis
Sammanfattning : Mast cells are innate immune cells, historically involved in allergy responses involving IgE. Through this, they have earned a reputation as a fairly detrimental cell type. Their beneficial roles remain somewhat enigmatic although they clearly have the ability to modulate the immune system. LÄS MER