Sökning: "Microvesicles"
Visar resultat 1 - 5 av 33 avhandlingar innehållade ordet Microvesicles.
1. Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis
Sammanfattning : Solid tumors are composed of cancer cells, as well as resident or infiltrating non-malignant cells that contribute to the malignant state in an ecosystem generally accepted as the tumor microenvironment. Microenvironmental tumor hypoxia is the foremost leading cause of angiogenesis, i.e. LÄS MER
2. On the Role of Polyamines and Microvesicles in Tumour Development. Regulation by Hypoxia and Implications for Therapeutic Intervention of Cancer
Sammanfattning : Novel strategies for specific tumour cell targeting are necessary in order to improve survival rates and to reduce side effects of current therapies in cancer patients. Hypoxia is a hallmark of solid tumours and one of the major driving forces for tumour progression. LÄS MER
3. Mechanisms of Shiga toxin-mediated signaling and toxicity
Sammanfattning : AbstractShiga toxin (Stx) is the main virulence factor of enterohemorrhagic Escherichia coli (EHEC). EHEC strains cause gastrointestinal infection and release Stx that can gain access to the circulation. Patients may develop hemolytic uremic syndrome with extensive kidney damage. LÄS MER
4. Cardiac hypertrophy : transcription patterns, hypertrophic progression and extracellular signalling
Sammanfattning : Background: The aim of this thesis was to study transcription patterns and extracellular signalling of the hypertrophic heart to better understand the mechanisms initiating, controlling and maintaining cardiac hypertrophy.Cardiac hypertrophy is a risk factor for cardiovascular morbidity and mortality. LÄS MER
5. Studies of the pathogenesis of Shiga toxin-producing Escherichia coli-induced hemolytic uremic syndrome
Sammanfattning : Hemolytic uremic syndrome (HUS) is characterized by non-immune hemolytic anemia, thrombocytopenia and acute kidney failure. The most common form of HUS is associated with gastrointestinal Shiga toxin-producing enterohemorrhagic Escherichia coli (EHEC) infection. EHEC are non-invasive strains with Shiga toxin as the unique virulence factor. LÄS MER