Sökning: "melanocytes"

Visar resultat 16 - 20 av 36 avhandlingar innehållade ordet melanocytes.

  1. 16. Biomarker Discovery in Cutaneous Malignant Melanoma : A Study Based on Tissue Microarrays and Immunohistochemistry

    Författare :Margrét Agnarsdóttir; Fredrik Ponten; Peter Naredi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibody-based proteomics; automated analysis; biomarker; immunohistochemistry; malignant melanoma; survival; tissue microarray; Tumour biology; Tumörbiologi; Pathology; Patologi; Molecular medicine; Molekylär medicin; Medical Science; Medicinsk vetenskap; Pathology; Patologi;

    Sammanfattning : The incidence of cutaneous malignant melanoma has increased dramatically in Caucasians the last few decades, an increase that is partly explained by altered sun exposure habits. For the individual patient, with a localized disease, the tumor thickness of the excised lesion is the most important prognostic factor. LÄS MER

  3. 17. Role of transcription factors in sensory neuron specification

    Författare :Andreas Montelius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The interface between our mind and the internal and external environments is the peripheral nervous system. A range of different sensory neuron subtypes detects cold, heat, pain, touch, and other stimuli. LÄS MER

  4. 18. Pheomelanin markers in melanoma with reference to their excretion into urine

    Författare :Dzeneta Nezirevic Dernroth; Bertil Kågedal; Christer Hansson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pheomelanin; melanoma; benzothiazole; aminohydroxyphenylalanine; diffuse melanosis; HILIC; Clinical chemistry; Klinisk kemi;

    Sammanfattning : Skin pigmentation is an important issue in most cultures. Until recently we have not understood the most important elements of pigmentation regarding detailed chemical structure. LÄS MER

  5. 19. Alopecia and vitiligo in autoimmune polyendocrine syndrome type I

    Författare :Håkan Hedstrand; Uppsala universitet; []
    Nyckelord :Medical sciences; APS I; autoantigen; vitiligo; alopecia areata; cDNA-library; immunoscreening; tyrosine hydroxylase; SOX9; SOX10; molecular mimicry; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Autoimmune polyendocrine syndrome type I (APS I) is a recessively inherited disease caused by mutations in a recently identified gene, AIRE, on human chromosome 21. APS I patients are affected by autoimmune destruction of multiple endocrine glands and other organs as well as ectodermal structures. LÄS MER

  7. 20. The interconnected KIT receptor and Microphthalmia-associated transcription factor axis in melanoma

    Författare :Bengt Phung; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Melanoma is an aggressive disease that arises from deregulated signaling events in melanocytes. The KIT receptor tyrosine kinase and the Microphthalmia-associated transcription factor (MITF) are two essential components that are required for the normal physiology of melanocyte development and function. LÄS MER