Sökning: "melanocytes"

Visar resultat 11 - 15 av 36 avhandlingar innehållade ordet melanocytes.

  1. 11. Interaction between chemicals and melanin : Role in the aetiology, diagnosis and treatment of melanoma

    Författare :Amilcar Eliseu Rato da Silva Roberto; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Sammanfattning : The incidence of malignant melanoma has continually increased over the past decades and the prognosisis poor after dissemination of metastases. A conspicuous feature of melanocytes and melanoma cells is the production of melanin. LÄS MER

  3. 12. Dissecting Phenotypic Variation in Pigmentation using Forward and Reverse Genetics

    Författare :Anders R Hellström; Uppsala universitet; []
    Nyckelord :Pigmentation; eumelanin; pheomelanin; knockout; Silver; SLC45A2; PMEL17; Sex-linked barring; CDKN2A; CDKN2B; ARF; chicken; Japanese quail; MEDICINE; MEDICIN; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Coat color and patterning phenotypes have been extensively studied as a model for advancing our understanding of the relationship between genetic and phenotypic variation. In this thesis, genes of relevance for pigment cell biology were investigated. The dissertation is divided in two parts. LÄS MER

  4. 13. Interaction between the nervous and immune systems in allergic contact dermatitis : a clinical and experimental study with emphasis on the role of VIP and serotonin

    Författare :Lena Bondesson Lundeberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :patch test; nickel sulphate; serotonin antagonists; VIP receptors; immunohistochemistry; ELISA; RIA; HPLC;

    Sammanfattning : The interaction between the nervous and immune systems was investigated in allergic contact dermatitis (ACD) with emphasis on the role of vasoactive intestinal peptide (VIP) and serotonin (S-HT). Dual dose-dependent effects of VIP on the migration of mononuclear and polymorphonuclear leukocytes were found. LÄS MER

  5. 14. Studies of transforming growth factor alpha in normal and abnormal growth

    Författare :Anna-Lotta Hallbeck; Åke Wasteson; Thomas Walz; Annelie Lindström; Carl-Henric Heldin; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-alpha; HER; EGFR; synovia; synovial sarcoma; RA; synovitis; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : Regulation of growth is of fundamental importance for development of the organism and to maintain health. The induction of cell proliferation and matrix production are influenced by several different signaling systems, most importantly by growth factors. LÄS MER

  7. 15. Assessment of prognostic markers in benign and malignant melanocytic tumours

    Författare :Vitalijs Svjatoha; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cutaneous melanoma is a malignant tumour that arises from pigmented skin cells – melanocytes, represents the most rapidly increasing cancer worldwide which is causing significant public health problem. During the past decade a significant progress has been made in the understanding of genesis and progression of melanocytic lesions. LÄS MER