Sökning: "lung physiology"

Visar resultat 6 - 10 av 56 avhandlingar innehållade orden lung physiology.

  1. 6. Lung mechanics and airway inflammation in murine models of asthma

    Författare :Sofia Jonasson; Josephine Hjoberg; Hedenstierna Göran; Carl Persson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allergic asthma; airway inflammation; murine models; lung mechanics; forced oscillation technique; airway reactivity; deep inhalations; oxidative stress; nitric oxide; glucocorticoids.; Clinical physiology; Klinisk fysiologi; klinisk fysiologi; Clinical Physiology;

    Sammanfattning : Allergic asthma is an inflammatory disease of the airways and is characterized by eosinophilic inflammation and increased airway reactivity. In the studies presented in this thesis, lung mechanics and measurements of airway reactivity were assessed in anaesthetized tracheostomized mice by using an animal ventilator (flexiVent®). LÄS MER

  3. 7. Cross-modal Imaging in Lung Research: From µCT dosimetry to synchrotron phase contrast microtomography biomechanical insights in preclinical lung injury models

    Författare :Richard Deyhle Jr; Malmö Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thermoluminescent Dosimetry; Optically stimulated luminescence OSL ; Computed tomography CT ; 4DCT; Phantoms; Imaging; X-rays; pre-clinical models; Pre-clinical; dosimetry: physical basis; biomedical strain; lung injury; mechanical ventilation; inflammation; lung function; synchrotron; histology; acute respiratory distress syndrome ARDS ; Ventilator Inudced Lung Injury VILI ; Histology; Forced Oscillation Technique FOT ; Divergence Theorem; Registration techniques;

    Sammanfattning : Lung diseases continue to present a large burden to public health, especially in industrialized countries. For abetter understanding of the underlying patho-mechanisms in lung related diseases as well as for testing theefficacy of novel therapies, preclinical studies in animal models are indispensable. LÄS MER

  4. 8. Artificial Neural Networks (ANN) in the Assessment of Respiratory Mechanics

    Författare :Gaetano Perchiazzi; Göran Hedenstierna; Björn Jonson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; artificial neural networks; respiratory system compliance; respiratory system resistance; respiratory system time constant; intrinsic positive end expiratory pressure; PEEPi; animal model; acute lung injury; oleic acid; Otis model; Fysiologi; Physiology; Fysiologi;

    Sammanfattning : The aim of this thesis was to test the capability of Artificial Neural Networks (ANN) to estimate respiratory mechanics during mechanical ventilation (MV). ANNs are universal function approximators and can extract information from complex signals. LÄS MER

  5. 9. Real-time breath gas analysis of carbon monoxide : laser-based detection and pulmonary gas exchange modeling

    Författare :Ramin Ghorbani; Florian M. Schmidt; Anders Blomberg; Christoffer Boman; Staffan Schedin; Jonathan Beauchamp; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; carbon monoxide CO ; pulmonary gas exchange; computational modeling; real-time breath gas analysis; single-exhalation profile; laser absorption spectroscopy; nonlinear least-squares fitting; breath sampling; baseline level; diurnal variation; healthy population; exposure study; fysik; Physics; Physiology; fysiologi;

    Sammanfattning : Breath gas analysis is a promising approach for non-invasive medical diagnostics and physiological monitoring. Real-time, breath-cycle resolved biomarker detection facilitates data interpretation and has the potential to improve the diagnostic value of breath tests as exhalation profiles carry spatiotemporal information about biomarker origin and gas exchange in the respiratory tract. LÄS MER

  7. 10. Investigating the Cause and Focusing on Treating Heart Failure-Related Target Organ Damage

    Författare :Lotte Vanherle; Vaskulär biologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heart Failure; Cystic fibrosis transmembrane regulator; Target organ damage; Brain; Lung;

    Sammanfattning : .... LÄS MER