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Visar resultat 11 - 15 av 103 avhandlingar som matchar ovanstående sökkriterier.

  1. 11. On Leukocyte Recruitment in Cholestatic Liver Injury

    Författare :Matthias Laschke; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Leukocyte and Liver; Inflammation; Cholestasis; Endothelium;

    Sammanfattning : Cholestasis is a frequent clinical syndrome, which is caused by a dysfunction in bile formation of the hepatocyte or from obstruction of the biliary tract. This is associated with inflammation of the liver tissue, resulting in severe liver injury. In this inflammatory process, leukocyte recruitment has emerged as a key feature. LÄS MER

  3. 12. Understanding the genetic architecture of fatty liver disease

    Författare :Jamialahmadi Oveis; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Non-alcoholic fatty liver disease; Polygenic risk score; Genomewide association studies; Mendelian Randomization;

    Sammanfattning : Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease, ranging from simple steatosis to more severe conditions, namely non-alcoholic steatohepatitis (NASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). NAFLD has a strong genetic component, and its heritability depends on environmental factors and ethnicity. LÄS MER

  4. 13. Ultrasound examination of lymph nodes in the hepato-duodenal ligament with special emphasis on patients with chronic liver diseases

    Författare :Kerstin Lyttkens; Lund Diagnostisk radiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ultrasound diagnosis; magnetic resonance imaging; hepato-duodenal ligament; lymph node enlargement; biliary cirrhosis; chronic active hepatitis; humoral immunoreactivity; hepatocellular damage; cholestasis.;

    Sammanfattning : The significance of finding lymph nodes in the hepato-duodenal ligament on ultrasound, with special emphasis on patients with inflammatory liver disease, has been evaluated. In one study a comparison was made with magnetic resonance imaging (MRI), which is another non-invasive imaging modality without the hazards of ionizing radiation. LÄS MER

  5. 14. The attenuation of the P53 response to DNA damage in rodent liver preneoplastic enzyme-altered foci

    Författare :Niklas Finnberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Enzyme-altered foci; p53; ATM; diethylnitrosamine; phenobarbital; liver; gene dosage;

    Sammanfattning : In connection with life-time bioassays in rodents, the liver is one of the organs most frequently affected. During the carcinogenic process, single preneoplastic hepatocytes develop into hepatocellular adenoma or carcinoma (HCC). LÄS MER

  7. 15. Role of membrane associated molecules in liver fibrosis

    Författare :Peter Rosenberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adhesion molecules; liver fibrosis; cholestasis; R-cadherin; N-CAM; EBP50; CFTR; cystic fibrosis; methotrexate; diabetes; over-weight; alcohol;

    Sammanfattning : The aim of the study was to evaluate the role of membrane associated proteins in tissue formation and remodeling, in normal embryogenesis and in liver disease. Molecules associated with cellular membranes provide a fundamental basis for cellular interactions during development, homeostasis and disease. LÄS MER