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  1. 1. Telomere length : dynamics and role as a biological marker in malignancy

    Författare :Ulrika Svenson; Göran Roos; Uwe Martens; Umeå universitet; []
    Nyckelord :Telomere length; peripheral blood; immune cells; breast cancer; renal cell carcinoma; biological marker; patologi; Pathology;

    Sammanfattning : Telomeres are protective structures at the end of our chromosomes, composed of multiple repeats of the DNA sequence TTAGGG. They are essential for maintaining chromosomal stability by preventing damage and degradation of the chromosome ends. LÄS MER

  3. 2. Estimation of wood fibre length distributions from censored mixture data

    Författare :Ingrid Svensson; Sara Sjöstedt - de Luna; Lennart Bondesson; Aila Särkkä; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; censoring; fibre length distribution; identifiability; increment core; length bias; mixture; stochastic EM algorithm; Mathematical statistics; Matematisk statistik;

    Sammanfattning : The motivating forestry background for this thesis is the need for fast, non-destructive, and cost-efficient methods to estimate fibre length distributions in standing trees in order to evaluate the effect of silvicultural methods and breeding programs on fibre length. The usage of increment cores is a commonly used non-destructive sampling method in forestry. LÄS MER

  4. 3. Variation in length of proteins by repeats and disorder regions

    Författare :Rauan Sagit; Arne Elofsson; Andrey Kajava; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein length; repeats; domain repeats; protein evolution; duplication; tandem duplication; intrinsic disorder; intrinsically disordered; variation in length; insertion; deletion; recombination; expansion; contraction; Biochemistry; biokemi;

    Sammanfattning : Protein-coding genes evolve together with their genome and acquire changes, some of which affect the length of their protein products. This explains why equivalent proteins from different species can exhibit length differences. LÄS MER

  5. 4. Evolution of Spur Length in a Moth-pollinated Orchid

    Författare :Elin Boberg; Jon Ågren; W. Scott Armbruster; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Platanthera bifolia; floral evolution; natural selection; pollination; spur length; population differentiation; divergent selection; disruptive selection; reproductive isolation; Biology; Biologi; Ecological Botany; Ekologisk botanik;

    Sammanfattning : There is considerable evidence that pollinator shifts can explain many differences in flower morphology between closely related plant species, but the extent to which pollinator shifts can explain the maintenance of among-population variation in floral traits within species is poorly known. In this thesis, I combined comparative and experimental approaches to examine the evolution of floral traits in the moth-pollinated orchid Platanthera bifolia. LÄS MER

  7. 5. Telomere length as prognostic parameter in chronic lymphocytic leukemia

    Författare :Pawel Grabowski; Göran Roos; Ylva Paulsson Karlsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; telomere length; chronic lymphocytic leukemia; prognosis; longitudinal sampling; genomic aberrations; IGHV; CD38; ZAP70; prognostic factors; Pathology; Patologi; patologi; Pathology;

    Sammanfattning : B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia among the adult population in western countries and accounts for 30-40% of all leukemias. With survival time ranging from months to decades, the clinical course of individual CLL patients is highly variable. LÄS MER