Sökning: "lehmann"

Visar resultat 1 - 5 av 22 avhandlingar innehållade ordet lehmann.

  1. 1. In vitro studies of retinoids and arsenic in non-M3 acute myeloid leukemia

    Författare :Sören Lehmann; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Huddinge University Hospital Department of Medicine; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Despite advances in the treatment of patients with acute myeloid leukemia (AML), the majority of the patients will die from their disease. The current intensive therapy for AML is also complicated my substantial morbidity and mortality and, as a result, many patients cannot be given the most effective therapy. LÄS MER

  3. 2. Synthesis and Structure-Activity Relationship. Studies of Non-Peptidic Urotensin II Receptor Agonists

    Författare :Fredrik Lehmann; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  4. 3. SOD1 misfolding and aggregation in ALS : in the light of conformation-specific antibodies

    Författare :Manuela Lehmann; Jonathan D. Gilthorpe; Stefan L. Marklund; Thomas Brännström; Ulrika Nordström; Elizabeth Fisher; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; antibodies; SOD1; disordered SOD1; patient-derived models; low oxygen tension; Immunotherapy;

    Sammanfattning : Mutations in the superoxide dismutase 1 (SOD1) gene are linked to the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). ALS-associated mutations affect the stability of the SOD1 protein and promote its unfolding. As a consequence, disordered SOD1 species can misfold and accumulate into insoluble aggregates. LÄS MER

  5. 4. Allosteric control of ALC1-catalyzed nucleosome remodeling

    Författare :Laura C. Lehmann; Sebastian Deindl; Stefan D. Knight; Felix Müller-Planitz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ALC1; CHD1L; ATP-dependent chromatin remodeling; nucleosome; allosteric regulation; autoinhibition; macro domain; PARP; ADP-ribosylation; DNA damage; acidic patch; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Sammanfattning : The genetic information of eukaryotic cells is packaged inside the nucleus as chromatin. This packaging restricts access to the DNA and therefore represents a barrier for processes such as DNA replication, repair, and gene expression. LÄS MER

  7. 5. Electrochemically etched pore arrays in silicon for X-ray imaging detectors

    Författare :Xavier Badel; Jan Linnros; Volker Lehmann; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Electrophysics; Elektrofysik; Electrophysics; Elektrofysik;

    Sammanfattning : Digital devices have now been introduced in many X-ray imaging applications, replacing slowly traditional photographic films. These devices are preferred as they offer real time imaging, easy handling and fast treatment of the images. LÄS MER