Sökning: "patient-derived models"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden patient-derived models.

  1. 1. Using patient-derived cell models to investigate the role of misfolded SOD1 in ALS

    Detta är en avhandling från Umeå : Umeå University

    Författare :Elin Forsgren; Umeå universitet.; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ALS; SOD1; patient-derived models; induced pluripotent stem cells; motor neurons; astrocytes; 20S proteasome low oxygen tension; misfolded SOD1; neurologi; Neurology;

    Sammanfattning : Protein misfolding and aggregation underlie several neurodegenerative proteinopathies including amyotrophic lateral sclerosis (ALS). Superoxide dismutase 1 (SOD1) was the first gene found to be associated with familial ALS. LÄS MER

  2. 2. Patient-derived xenografts as preclinical models of neuroblastoma

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Noémie Braekeveldt; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; [2017]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : .... LÄS MER

  3. 3. Development and application of a patient-derived xenograft platform to test anticancer agents

    Detta är en avhandling från Gothenburg : University of Gothenburg

    Författare :Berglind Einarsdottir; Göteborgs universitet.; Gothenburg University.; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; malignant melanoma; patient-derived xenografts; MTH1; pre-clinical trial; Karonudib;

    Sammanfattning : Malignant melanoma is the most aggressive form of skin cancer and incidence rates are on the rise. Despite recent improvements in treatment options, the disease still remains lethal. Which calls for expedited solutions. LÄS MER

  4. 4. SOD1 misfolding and aggregation in ALS in the light of conformation-specific antibodies

    Detta är en avhandling från Umeå : Umeå university

    Författare :Manuela Lehmann; Umeå universitet.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; antibodies; SOD1; disordered SOD1; patient-derived models; low oxygen tension; Immunotherapy;

    Sammanfattning : Mutations in the superoxide dismutase 1 (SOD1) gene are linked to the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). ALS-associated mutations affect the stability of the SOD1 protein and promote its unfolding. As a consequence, disordered SOD1 species can misfold and accumulate into insoluble aggregates. LÄS MER

  5. 5. Experimental models of pediatric brain tumors. Establishment, immunophenotyping and clinical implications

    Detta är en avhandling från Lund University, Faculty of Medicine

    Författare :Emma Sandén; Lunds universitet.; Lund University.; [2016]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pediatric Brain Tumor; Experimental model; Immunotherapy; Immune monitoring; Medulloblastoma;

    Sammanfattning : Brain tumors are the most common solid tumors in children. Current treatment protocols fail in 25% of patients and are associated with significant long-term adverse effects in survivors. LÄS MER