Sökning: "patient-derived models"
Visar resultat 1 - 5 av 43 avhandlingar innehållade orden patient-derived models.
1. Using patient-derived cell models to investigate the role of misfolded SOD1 in ALS
Sammanfattning : Protein misfolding and aggregation underlie several neurodegenerative proteinopathies including amyotrophic lateral sclerosis (ALS). Superoxide dismutase 1 (SOD1) was the first gene found to be associated with familial ALS. LÄS MER
2. Patient-derived xenografts as preclinical models of neuroblastoma
Sammanfattning : .... LÄS MER
3. Development and application of a patient-derived xenograft platform to test anticancer agents
Sammanfattning : Malignant melanoma is the most aggressive form of skin cancer and incidence rates are on the rise. Despite recent improvements in treatment options, the disease still remains lethal. Which calls for expedited solutions. LÄS MER
4. Novel immunotherapies for metastatic melanoma - from mouse models towards clinical trials
Sammanfattning : Immunotherapies including checkpoint blockade and adoptive T cell transfer (ACT) show great promise for the treatment of melanoma, with long-term effects in some patients. However, around half of the patients with metastatic malignant melanoma will not be cured with available therapies today, and these patients require other treatment strategies. LÄS MER
5. SOD1 misfolding and aggregation in ALS : in the light of conformation-specific antibodies
Sammanfattning : Mutations in the superoxide dismutase 1 (SOD1) gene are linked to the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). ALS-associated mutations affect the stability of the SOD1 protein and promote its unfolding. As a consequence, disordered SOD1 species can misfold and accumulate into insoluble aggregates. LÄS MER