Sökning: "late-stage functionalization"
Hittade 4 avhandlingar innehållade orden late-stage functionalization.
1. Iridium-Catalyzed C−H Activation Methods for Late-Stage Functionalization of Pharmaceuticals
Sammanfattning : C-H activations have over the recent decades risen from a mere curiosity to a viable synthetic strategy. However, challenges in terms of accessible transformations, selectivity and functional group tolerance limit the widespread applicability of this approach. LÄS MER
2. New Strategies for Transition Metal-mediated (Hetero)arene Functionalization
Sammanfattning : This thesis describes new approaches to achieve efficient and selective (hetero)arene derivatization using transition metals. The main focus falls on the use of strategies based on C–H activation and organo-main group reactivity to render the synthesis of various (hetero)arene derivatives more direct, efficient, regioselective and sustainable. LÄS MER
3. C–H and Si–H functionalization using redox-active diazo compounds and decarboxylative coupling
Sammanfattning : The work presented in this thesis is based on two basic organic chemistry concepts: carbene catalysis and radical coupling reactions. Diazo compounds in the presence of transition-metal catalysts are known to be excellent reagents for the construction of C–X bonds (X = C, Si, N, O, etc.) under mild conditions. LÄS MER
4. Multimodal Porphyrin-Based Conjugates : Synthesis and characterization for applications as amyloid ligands, photodynamic therapy agents and chiroptical materials
Sammanfattning : Organic compounds that interact both with certain biological targets and display specific photophysical properties can be utilized as molecular tools to visualize and possibly effect disease related processes taking place in living organisms. In this regard, porphyrins are a class of naturally occurring molecules that possess intriguingly interesting photophysical properties where they can act as luminescent probes by emitting detectable light, as well as photosensitizers in the light mediated therapy called photodynamic therapy. LÄS MER
