Sökning: "inhibitor-1"

Visar resultat 1 - 5 av 58 avhandlingar innehållade ordet inhibitor-1.

1. 1. Structure-function studies of plasminogen activator inhibitor-1

   Författare :Guang-Chao Sui; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :PAI-1; site-directed mutagenesis; structure and function; stability;

   Sammanfattning : Plasminogen activator inhibitor-I (PAI-1) is an important physiological inhibitor of tissue-type plasminogen activator (tPA) and urine-type plasminogen activator (uPA). High plasma levels of PAI-1 correlate to thrombotic disease, and low levels can be connected to a bleeding tendency. LÄS MER

3. 2. Plasminogen Activator Inhibitor-1 and the Insulin Resistance Syndrome

   Författare :Liisa Byberg; Anders Hamsten; Uppsala universitet; []
   Nyckelord :Medical sciences; PAI-1; insulin sensitivity; physical activity; birth weight; fatty acids; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Geriatrics; geriatrik;

   Sammanfattning : In this thesis, different aspects of the insulin resistance syndrome in relation to plasminogen activator inhibitor-1 (PAI-1) activity are investigated in a longitudinal population-based study. Participants were men investigated at ages 50 and 70 with follow-up data on mortality. LÄS MER

4. 3. Aspects of Plasminiogen Activator Inhibitor 1 in Metabolic Syndrome

   Författare :Karin Mossberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PAI-1; metabolic syndrome; obesity; type 2 diabetes; cardiovascular disease; fibrinolysis; thrombi; plasma; platelets; adipose tissue; mRNA; qPCR; reference gene;

   Sammanfattning : Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of the fibrinolytic system and binds irreversibly to tissue-type plasminogen activator (t-PA), and thereby inhibits the protective action of t-PA against thrombus formation. Elevated levels of plasma PAI-1 is observed in subjects with type 2 diabetes (T2D) and the metabolic syndrome (MetS), which is a combination of metabolic features including obesity. LÄS MER

5. 4. Tissue-type plasminogen activator : molecular interactions with plasminogen activator inhibitor-1 and endothelial cell-surface proteins

   Författare :Maria Ljung; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : .... LÄS MER

7. 5. Plasminogen Activator Inhibitor 1 in Platelets - Studies of Synthesis, Activity, and Glycosylation Patterns

   Författare :Helén Brogren; Göteborgs universitet; []
   Nyckelord :PAI-1; platelets; plasma; fibrinolysis; synthesis; polymorphism; glycosylation; activity; platelet mRNA;

   Sammanfattning : Plasminogen activator inhibitor 1 (PAI-1) is the main physiological inhibitor of tissue-type plasminogen activator. Thus PAI-1 plays an important role in decreasing the fibrinolytic activity in human blood. PAI-1 is present in high concentrations in platelets and also in low concentrations in plasma, but the source of plasma PAI-1 is not known. LÄS MER