Sökning: "industrial systems biology"

Visar resultat 6 - 10 av 44 avhandlingar innehållade orden industrial systems biology.

  1. 6. Metabolic Engineering of Saccharomyces cerevisiae for Sesquiterpene Production

    Författare :Gionata Scalcinati; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Systems Biology; Saccharomyces cerevisiae.; Evolutionary engineering; Metabolic Engineering; Microrefinery; Cell factory; Synthetic Biology;

    Sammanfattning : Industrial biotechnology aims to develop robust “microbial cell factories”, to produce an array of added value chemicals presently dominated by petrochemical processes. The exploitation of an efficient microbial production as sustainable technology has an important impact for our society. LÄS MER

  3. 7. On thermodynamic and kinetic constraints in autotrophic metabolism

    Författare :Markus Janasch; Elton P. Hudson; Bas Teusink; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; autotrophic metabolism; cyanobacteria; microbial metabolic engineering; computational systems biology; biochemical thermodynamics; kinetic modelling; Bioteknologi; Biotechnology;

    Sammanfattning : Earth has entered a new geological epoch, the Anthropocene, defined by humanity’s impact on the environment with increased emissions of CO2 due to burning of fossil resource as a major contributor. To ensure a sustainable future, humanity has to move towards a circular economy, where released CO2 is re-captured and turned into resources. LÄS MER

  4. 8. An insight towards food-related microbial sets through metabolic modelling and functional analysis

    Författare :Simonas Marcisauskas; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; RAVEN; gut; systems biology; comparative genomics; Kluyveromyces marxianus; bile acids; genome-scale metabolic model; next-generation sequencing; transcriptomics; thermotolerance;

    Sammanfattning : The dietary food digestion depends on the human gastrointestinal tract, where host cells and gut microbes mutually interact. This interplay may also mediate host metabolism, as shown by microbial-derived secondary bile acids, needed for receptor signalling. Microbes are also crucial in the production of fermented foods, such as wine and dairy. LÄS MER

  5. 9. Exploring genetic heterogeneity in cancer using high-throughput DNA and RNA sequencing

    Författare :Erik Fasterius; Cristina Al-Khalili Szigyarto; Mathias Uhlén; Peter-Bram ’t Hoen; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; bioinformatics; RNA-seq; WGS; WES; systems biology; variant analysis; single nucleotide variant; gene expression; machine learning; clustering; open source; R; bioconductor; Python; Bioteknologi; Biotechnology;

    Sammanfattning : High-throughput sequencing (HTS) technology has revolutionised the biomedical sciences, where it is used to analyse the genetic makeup and gene expression patterns of both primary patient tissue samples and models cultivated in vitro. This makes it especially useful for research on cancer, a disease that is characterised by its deadliness and genetic heterogeneity. LÄS MER

  7. 10. Microbial Synthetic Biology, Systems Metabolic Engineering and Enzyme Engineering for Advanced Microbial Biodiesel Production with Saccharomyces cerevisiae

    Författare :Juan Octavio Valle Rodriguez; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; protein rational engineering; wax ester synthase; hydrolase; advanced biofuel; fatty acid metabolism; directed evolution; chromosomal delta-integration;

    Sammanfattning : The continuous requirement of transportation biofuels has brought the necessity to establish alternatives permitting low-cost production of biodiesel while being environmentally friendly. Biodiesel production was achieved utilizing Saccharomyces cerevisiae by employing respective enzymes that catalyze the synthesis of fatty acid ethyl esters (FAEEs) based on fatty acyl-CoA molecules and ethanol. LÄS MER