Sökning: "incretin hormones"

Visar resultat 11 - 15 av 19 avhandlingar innehållade orden incretin hormones.

  1. 11. Mechanism-Based Modelling of Clinical and Preclinical Studies of Glucose Homeostasis

    Författare :Oskar Alskär; Maria C Kjellsson; Mats O Karlsson; Jenny Y. Chien; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucose homeostasis; pharmacometrics; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Sammanfattning : Glucose is an important nutrient and energy source in the body. However, too high concentration in the blood is harmful and may lead to several complications developing over time. It was estimated that 5 million people in the world died from complications related to diabetes during 2015. LÄS MER

  3. 12. Pharmacometric Models of Glucose Homeostasis in Healthy Subjects and Diabetes Patients

    Författare :Rikke Meldgaard Røge; Maria Kjellsson; Niels Rode Kristensen; Søren Klim; Mats Karlsson; Roman Hovorka; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glucose homeostasis; Type 2 diabetes; IGI model; Mechanismbased; NONMEM; pharmacometrics;

    Sammanfattning : Diabetes is a group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. Several models have been developed for describing the glucose-insulin system. LÄS MER

  4. 13. Molecular regulation of hormone secretion, growth and apoptosis of GLP-1-producing cells

    Författare :Camilla Kappe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type 2 diabetes (T2D) spreads like an epidemic in today’s society, and there is a great need for new and improved treatments. T2D is characterized by hyperglycemia, resulting from impaired insulin production and insulin resistance in peripheral tissues. LÄS MER

  5. 14. Mechanism-Based Modeling of the Glucose-Insulin Regulation during Clinical Provocation Experiments

    Författare :Petra Jauslin-Stetina; Mats Karlsson; Nicolas Frey; Philippe Jacqmin; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; Glucose homeostasis; Type 2 diabetes; IVGTT; OGTT; Meal test; Circadian variation; Mechanism-based; NONMEM; Farmakokinetik Farmakoterapi;

    Sammanfattning : Type 2 diabetes is a complex chronic metabolic disorder characterized by hyperglycemia associated with a relative deficiency of insulin secretion and a reduced response of target tissues to insulin. Considerable efforts have been put into the development of models describing the glucose-insulin system. LÄS MER

  7. 15. The endocrine heart - metabolic actions of atrial natriuretic peptide

    Författare :Amra Jujic; Kardiovaskulär forskning - hypertoni; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Atrial natriuretic peptide; type 2 diabetes; rs5068; insulin resistance; glucose dependent insulinotropic peptide; glucagon-like peptide-1; left ventricular hypertrophy;

    Sammanfattning : Abstract The natriuretic peptides (NPs), namely atrial natriuretic peptide (ANP) and bran natriuretic peptide (BNP), which are secreted from cardiomyocytes in response to cardiac wall stress, play a significant role in the regulation of blood pressure, intravascular volume, and cardiac remodeling. Recently, NPs emerged as hormones with metabolic actions such as inhibition of the renin-angiotensin system and inhibition of inflammation, together with lipolysis and adipose tissue browning. LÄS MER