Sökning: "IVGTT"

Hittade 4 avhandlingar innehållade ordet IVGTT.

  1. 1. Mechanism-Based Modeling of the Glucose-Insulin Regulation during Clinical Provocation Experiments

    Författare :Petra Jauslin-Stetina; Mats Karlsson; Nicolas Frey; Philippe Jacqmin; Uppsala universitet; []
    Nyckelord :Pharmacokinetics Pharmacotherapy; Glucose homeostasis; Type 2 diabetes; IVGTT; OGTT; Meal test; Circadian variation; Mechanism-based; NONMEM; Farmakokinetik Farmakoterapi;

    Sammanfattning : Type 2 diabetes is a complex chronic metabolic disorder characterized by hyperglycemia associated with a relative deficiency of insulin secretion and a reduced response of target tissues to insulin. Considerable efforts have been put into the development of models describing the glucose-insulin system. LÄS MER

  3. 2. Melatonin receptors in pancreatic islets - Linking a genetic variant to functional phenotype

    Författare :Cecilia Nagorny; Diabetes - molekylär metabolism; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melatonin receptor; knock out mice; IVGTT; OGTT; ITT; Hyperinsulinemic clamp; MTNR1B; MT2;

    Sammanfattning : Defective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. LÄS MER

  4. 3. Fluid and nutrition support before total hip replacement surgery

    Författare :Stefan Ljunggren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Surgical trauma results in a variety of physiological reactions in the body, including transient insulin resistance. The effect of surgery on postoperative wellbeing has been linked to this insulin resistance, which can be prevented through the ingestion of carbohydrate-rich liquid before surgery. LÄS MER

  5. 4. Metabolic alterations and adipose tissue dysfunction in individuals with a family history of type 2 diabetes

    Författare :Josefin Henninger; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Typ 2 diabetes; Fettvävnadsdysfuntion; Förstagradssläktningar;

    Sammanfattning : ABSTRACT Aims The overall aim of this doctoral thesis was to further examine the anthropometric, metabolic and adipose tissue dysfunctions, as well as explore novel metabolites, associated with type 2 diabetes mellitus (T2D), examining individuals both with and without known genetic predisposition to T2D. This thesis is part of the research conducted at Lundberg laboratory for diabetes research, Institute of Medicine, Sahlgrenska Academy, at Gothenburg University. LÄS MER