Sökning: "hypoxanthine"

Visar resultat 11 - 15 av 15 avhandlingar innehållade ordet hypoxanthine.

1. 11. Protein folding, stability and recognition

   Författare :Jianxin Duan; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Protein; folding; stability; recognition; molecular dynamics; protein-DNA interactions; simulation;

   Sammanfattning : Proteins make up for most of the dry mass of a cell and they are highly involved in virtually all cellular processes. The importance of the proteins is reflected by frequent association between dysfunctional proteins and diseases. Proteins have also wide applications in industries. LÄS MER

3. 12. Mutation profile at the hprt locus in T-cells of non-smoking males

   Författare :Anne-May Österholm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :human T-cells; hprt mutation; in vivo; deletion; splicing; base substitution;

   Sammanfattning : Extensive studies have been done on mutations in several marker genes in order to predict health consequences such as carcinogenesis. However, more information about mutations arising in vivo in somatic cells is needed to understand the relationship between the different factors involved in mutagenesis such as DNA damage, DNA repair capacity and individual susceptibility, and to elucidate the influence of endogenous mechanisms and environmental exposures. LÄS MER

4. 13. HPRT mutational spectra and microsatellite DNA instability in HNPCC and lung cancer patients

   Författare :Peter Hackman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Somatic gene mutation; mutational spectra; HPRT gene; lung cancer; smoking; hMLH1 gene; HNPCC; microsatellite instability; mismatch repair; T-cells;

   Sammanfattning : The, general aims of this work have been to explore the use of microsatellite DNA length variation and mutational spectra of the hypoxanthine guanine phosphoribosyltransferase (HPRT) locus in T-cells as tools for a better understanding of human somatic mutagenesis in vivo. In particular (a) how inherited mismatch repair (MMR) deficiency may affect the stability of microsatellite DNA and the mutational spectrum at the HPRT locus, and (b) how the mutational spectrum at the HPRT locus is influenced by smoking, and by predisposition to lung cancer among never smokers. LÄS MER

5. 14. Regulation by glutamate- and adenosine-receptors of dopamine and acetylcholine release from rat striatal slices

   Författare :Shaoyu Jin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :striatum; dopamine; acetylcholine; adenosine receptors; glutamatereceptors. ISBN 91-628-2599-2;

   Sammanfattning : The striatum, which is critically involved in sensory motor integration, receives an excitatory glutamatergic input from the cerebral cortex and the thalamus. The effects of the glutamatergic stimulation are modulated by dopamine (DA) released from a prominent dopaminergic input, acetylcholine (ACh) released from cholinergic interneurons and by the ubiquitous neuromodulator adenosine. LÄS MER

7. 15. Pharmacological and molecular investigations on the mechanisms underlying resistance of human leukaemia cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine

   Författare :Alan Kambiz Fotoohi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The goal of this thesis has been to elucidate the mechanisms underlying resistance to methotrexate (MTX), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG), the antimetabolites widely used in treatment of childhood leukemia, as well as to determine the influence of 7-hydroxymethotrexate (7-OHMTX), the major metabolite of MTX, on the therapeutic action of MTX. Resistant sublines of leukemic cell lines were developed by long-term exposure to stepwise increasing concentrations of these different agents. LÄS MER