Sökning: "human immunoglobulin G"

Visar resultat 1 - 5 av 35 avhandlingar innehållade orden human immunoglobulin G.

  1. 1. Aspects of the regulation of human sperm motility

    Författare :Pär K G Leijonhufvud; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In this thesis I address some of the possible causes for oligozoospermia and low sperm motility, two factors that, singly or in combination, are often seen in cases of male subfertility. In the first study we evaluated the effect on human spermatozoa of the toxicity of compounds present in diesel exhaust. LÄS MER

  3. 2. Production of polyclonal antibodies in rabbits and chickens immunised with human immunoglobulin G : A study of the utility of egg yolk antibody production as a substitute for rabbit serum antibody production

    Författare :Lise Svendsen Bollen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Laboratory animals; antibody production; egg yolk; adjuvants; antibody response; avidity; Försöksdjursvetenskap; Laboratory animal science; Försöksdjursvetenskap; zoologisk utvecklingsbiologi; Animal Development;

    Sammanfattning : The utility of chicken egg yolk antibodies as an alternative to rabbit antisera was studied by comparing antibody and avidity development in immunised animals (15 rabbits and 30 chickens) during a one-year immunisation scheme. Human IgG was used as the model antigen and the efficacy of three adjuvants, Freund's Complete Adjuvant, Freund's Incomplete Adjuvant and Hunter's TiterMax, was compared. LÄS MER

  4. 3. Immunoglobulin-binding bacterial surface proteins; biomedical tools and virulence factors

    Författare :Britt-Marie Kihlberg; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Phagocytosis; M-like protein; M protein; Protein L; Protein G; Ig-binding; Streptococcus pyogenes; Fc Receptors; mykologi; virologi; bakteriologi; Mikrobiologi; mycology; virology; bacteriology; Microbiology; Cysteine proteinase; Streptolysin;

    Sammanfattning : Many bacteria express immunoglobulin(Ig)-binding proteins that interact with Ig in a non-immune manner. Several of these Ig-binding bacterial proteins have been well characterized and are widely used as reagents for analysis and purification of Ig's. LÄS MER

  5. 4. Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals

    Författare :Britta Granath; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anti-drug antibodies; immunogenicity; biopharmaceuticals; immunoglobulin; 3R;

    Sammanfattning : The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of the drug and autoimmune conditions if the administered drug is analogous to endogenous proteins. LÄS MER

  7. 5. Development of Capacitive Biosensors for Monitoring of Bacterial Toxins and Other Biomolecules

    Författare :Mahmoud Labib; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; enzyme-linked immunosorbent assay; self-assembled monolayers; competitive capacitive biosensing; cholera toxin; Capacitive biosensor; surface plasmon resonance; staphylococcal enterotoxin B; nanogold; human immunoglobulin G; glucose;

    Sammanfattning : Sensing and quantification of biomolecules are becoming increasingly important in medical diagnostics, bioprocess technology and recently in homeland security. The majority of techniques currently employed to interrogate biomolecules require some type of radio-, enzymatic- or fluorescent-labeling. LÄS MER