Sökning: "Streptolysin"
Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet Streptolysin.
1. Immunoglobulin-binding bacterial surface proteins; biomedical tools and virulence factors
Sammanfattning : Many bacteria express immunoglobulin(Ig)-binding proteins that interact with Ig in a non-immune manner. Several of these Ig-binding bacterial proteins have been well characterized and are widely used as reagents for analysis and purification of Ig's. LÄS MER
2. Interactions between Streptococcus pyogenes and the human immune defence
Sammanfattning : Streptococcus pyogenes is an important human pathogen frequently colonizing the throat and skin of humans. To facilitate colonization and spread and to avoid the host immune defence, streptococci are endowed with a variety of virulence factors, two of which are investigated in this thesis namely streptolysin O (SLO) and M protein. LÄS MER
3. On the effects of Streptococcal NAD+-glycohydrolase and Streptolysin O on macrophages
Sammanfattning : SummaryThe human pathogen Streptococcus pyogenes (GAS) causes both superficial infections, such as strep throat, and invasive infections, such as necrotizing fasciitis, and is responsible for about half a million deaths each year. The number of GAS infections have increased since the 1980’s, due to the emergence of a M1T1 strain that has become widely disseminated. LÄS MER
4. Regulation of inflammasomes by host- and pathogen-derived factors
Sammanfattning : The term inflammasome was first coined in 2002 and describes an intracellular multiprotein complex mediating inflammation by inducing the release of pro-inflammatory cytokines (IL-1β and IL-18) and a lytic form of cell death called pyroptosis. Since then, an impressive amount of research has revealed many details about the mechanisms of inflammasome activation as well as the functional relevance of inflammasome activation in different contexts. LÄS MER
5. Influence of MHC class I peptide interaction on antigen presentation in normal and malignant cells
Sammanfattning : The presentation of MHC class I peptide complexes in normal and malignant cells was studied. An HLA A11 binding motif was defined by comparing synthetic peptide analogues of a known cytotoxic T Iymphocyte (CTL) target epitope for induction of surface A11 expression and triggering of cytotoxic activity. LÄS MER