Sökning: "anti-drug antibodies"

Hittade 5 avhandlingar innehållade orden anti-drug antibodies.

1. 1. Anti-drug antibodies in patients with multiple sclerosis

   Författare :Malin Ryner; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Multiple sclerosis (MS) is an inflammatory disease affecting the brain and spinal cord and it is the main cause of neurological disability among young adults. Recombinant interferon beta (IFNβ) and natalizumab are commonly used disease-modifying drugs that reduce disease severity. LÄS MER

3. 2. Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals

   Författare :Britta Granath; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anti-drug antibodies; immunogenicity; biopharmaceuticals; immunoglobulin; 3R;

   Sammanfattning : The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of the drug and autoimmune conditions if the administered drug is analogous to endogenous proteins. LÄS MER

4. 3. Anti-CD20 therapy in multiple sclerosis : clinical and paraclinical outcomes

   Författare :Alexander Juto; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Multiple sclerosis is a chronic inflammatory disease of the central nervous system and the most common non-traumatic cause of neurological disability in young adults. Rituximab is a B-cell depleting drug targeting the CD20 epitope on B-cells, which drive inflammation in relapsing-remitting multiple sclerosis by acting as antigen-presenting cells to activate T-cell responses against central nervous system autoantigens. LÄS MER

5. 4. Immunogenicity of biopharmaceuticals in chronic inflammatory diseases

   Författare :Christina Hermanrud; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Multiple sclerosis (MS) and rheumatoid arthritis (RA) are chronic inflammatory diseases where genetic and environmental factors influence the pathogenesis. MS is a disease of the central nervous system, while RA primarily affects the joints. LÄS MER

7. 5. Studies on biological treatment and biomarkers in systemic lupus erythematosus : longterm effects, risk factors and predictors of response

   Författare :Francesca Faustini; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which several immune mechanisms are involved in a complex interplay. B-cells are considered to be a major player in the pathophysiology of the disease, and the advent of B-cell depletion therapy (BCDT), has brought much promise. LÄS MER