Sökning: "M protein"

Visar resultat 1 - 5 av 598 avhandlingar innehållade orden M protein.

1. 1. Protein Expression Profiling of Cancer Biomarkers

   Författare :Kristina Magnusson; Fredrik Pontén; Karin Jirström; Anna Dimberg; Tibor Tot; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibody-based proteomics; Biomarker; SATB2; Colorectal cancer; ANLN; Breast cancer; CD93; Angiogenesis; Pathology; Patologi;

   Sammanfattning : The Human Protein Atlas project is a Swedish research initiative that uses antibody-based proteomics for large scale protein profiling in human tissues and cells. Affinity-purified antibodies are produced within the project and used for immunohistochemical staining on tissue micro arrays (TMAs) in order to map the human proteome and publish the result in a protein atlas (www. LÄS MER

3. 2. Molecular principles of protein stability and protein-protein interactions

   Författare :Christofer Lendel; Per-Åke Nygren; Christopher M. Dobson; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; binding thermodynamics; induced fit; molten globule; NMR spectroscopy; protein engineering; protein-protein interactions; protein stability; protein structure.; Structural biochemistry; Strukturbiokemi;

   Sammanfattning : Proteins with highly specific binding properties constitute the basis for many important applications in biotechnology and medicine. Immunoglobulins have so far been the obvious choice but recent advances in protein engineering have provided several novel constructs that indeed challenge antibodies. LÄS MER

4. 3. Protein-Protein Interactions Affecting Protein-Surface Interactions

   Författare :Peter H. Warkentin; Jeff M. Schakenraad; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : The focus of this thesis is the behaviour of proteins towards surfaces in the presence of other protein species. General protein-protein interactions of some plasma proteins are investigated in the first four papers. The proteins, immunoglobulin G, albumin, and fibrinogen, are analysed in solutions of single proteins as well as controlled mixtures. LÄS MER

5. 4. Neuron-to-neuron propagation of neurodegenerative proteins; relation to degradative systems

   Författare :Jakob Domert; Martin Hallbeck; Jan Marcusson; Lars Tjernberg; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-to-cell transfer; beta-amyloid; Alzheimer s disease; degradation; proteasome; alpha-synuclein; Parkinson s disease; high throughput screening model;

   Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are defined by neurodegeneration and accumulations of misfolded proteins that spread through the brain in a well characterized manner. In AD these accumulations consist mainly of β-amyloid (Aβ) and tau, while in PD, α-synuclein (α-syn) make up the characteristic lewy pathology. LÄS MER

7. 5. Molecular-dynamics simulations of polymeric surfaces for biomolecular applications

   Författare :Stela Andrea Muntean; M.A.J. Michels; M.W.J. Prins; A.V. Lyulin; Technische Universiteit Eindhoven; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polystyrenes; Molecular Dynamics; Computer Simulation; Water; Molecules; Atoms; Hydrophilicity; Biosensors; Myoglobin; Physics; Fysik;

   Sammanfattning : In-vitro diagnostics plays a very important role in the present healthcare system. It consists of a large variety of medical devices designed to diagnose a medical condition by measuring a target molecule in a sample, such as blood or urine. LÄS MER