Sökning: "Britta Granath"

Hittade 1 avhandling innehållade orden Britta Granath.

  1. 1. Development of immunogenicity models in mice for improved risk assessment of biopharmaceuticals

    Detta är en avhandling från Göteborg : University of Gothenburg

    Författare :Britta Granath; Göteborgs universitet.; Gothenburg University.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anti-drug antibodies; immunogenicity; biopharmaceuticals; immunoglobulin; 3R;

    Sammanfattning : The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins including monoclonal antibodies (mAb) can lead to adverse events and clinical complications. These include reduced effect of the drug and autoimmune conditions if the administered drug is analogous to endogenous proteins. LÄS MER