Sökning: "hepatocyte"
Visar resultat 6 - 10 av 83 avhandlingar innehållade ordet hepatocyte.
6. Thromboinflammation : in a Model of Hepatocyte Transplantation
Sammanfattning : Hepatocyte transplantation is an attractive method for the treatment of metabolic liver disease and acute liver failure. The clinical application of this method has been hampered by a large initial loss of transplanted cells. LÄS MER
7. The role of peridontitis and hepatocyte growth factor in systemic inflammation
Sammanfattning : An essential goal in addressing inflammation is the return of tissue to homeostasis. Persistent infections often cause prolonged response and accumulation of immune cells, inducing imbalance in pro- and anti-inflammatory mediators, tissue destruction, and chronic inflammation. LÄS MER
8. Experimental studies on the effects of hepatocyte-based liver support
Sammanfattning : Liver transplantation is limited by lack of donors and consequently there is a need to develop liver support/replacement therapies, such as hepatocyte transplantation (HcTx) and artificial livers. In the present thesis, the effects of these therapies were investigated. First, we established a technique of isolating fetal hepatocytes (FH). LÄS MER
9. In vitro and in silico Predictions of Hepatic Transporter-Mediated Drug Clearance and Drug-Drug Interactions in vivo
Sammanfattning : The liver is the major detoxifying organ, clearing the blood from drugs and other xenobiotics. The extent of hepatic clearance (CL) determines drug exposure and hence, the efficacy and toxicity associated with exposure. Drug-drug interactions (DDIs) that alter the hepatic CL may cause more or less severe outcomes, such as adverse drug reactions. LÄS MER
10. Magnetic Resonance Imaging of the Hepatobiliary System Using Hepatocyte-Specific Contrast Media
Sammanfattning : There are two Gadolinium-based liver-specific contrast media for Magnetic Resonance Imaging on the market, Gd-BOPTA (MultiHance®, Bracco Imaging, Milan, Italy) and Gd-EOB-DTPA (Primovist®, Bayer Schering Pharma, Berlin, Germany). The aim of this study in two parts was to evaluate the dynamics of biliary, parenchymal and vascular enhancement using these contrast media in healthy subjects. LÄS MER