Sökning: "hepatocyte isolation"

Hittade 4 avhandlingar innehållade orden hepatocyte isolation.

  1. 1. Mechanistic analyses of hepatocyte plasticity

    Författare :Nuria Oliva-Vilarnau; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Adult hepatocytes are highly plastic cells which have a molecular toolbox for efficient regeneration. Yet, end stage liver diseases are becoming an increasing clinical burden. LÄS MER

  3. 2. In vitro and in silico Predictions of Hepatic Transporter-Mediated Drug Clearance and Drug-Drug Interactions in vivo

    Författare :Anna Vildhede; Per Artursson; Maria Karlgren; Maria Kjellsson; Ulf Norinder; Kim Brouwer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; OATP1B1; OATP1B3; OATP2B1; NTCP; drug transporters; human hepatocytes; atorvastatin; pitavastatin; proteomics; sandwich-cultured human hepatocytes; SCHH; mechanistic modeling; in vitro-in vivo extrapolation; transport inhibition; hepatic uptake; hepatocyte isolation; transporter contribution; Biopharmaceutics; Biofarmaci;

    Sammanfattning : The liver is the major detoxifying organ, clearing the blood from drugs and other xenobiotics. The extent of hepatic clearance (CL) determines drug exposure and hence, the efficacy and toxicity associated with exposure. Drug-drug interactions (DDIs) that alter the hepatic CL may cause more or less severe outcomes, such as adverse drug reactions. LÄS MER

  4. 3. Hepatocyte transplantation : experimental and clinical studies

    Författare :Carl Jorns; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hepatocyte transplantation is an experimental treatment for patients with end-stage liver disease and inborn metabolic liver disorders. Studies in animal models and human trials have shown that allogenic hepatocytes infused through the portal vein physiologically integrate into the liver parenchyma, replacing missing liver function. LÄS MER

  5. 4. Human amnion epithelial stem cells as a therapy for liver disease

    Författare :Raghuraman Chittoor Srinivasan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Placenta-derived stem cells have been proposed as potential new treatments for acute and congenital liver diseases. Of all the different perinatal tissues, amnion membrane and isolated amnion epithelial cells have been shown to be an outstanding readily available source of multipotent stem cells. LÄS MER