Sökning: "hepatocyte"
Visar resultat 21 - 25 av 83 avhandlingar innehållade ordet hepatocyte.
21. Cellular replacement therapy for liver disease
Sammanfattning : Liver disease is a major health problem worldwide. The liver performs a wide range of functions, which the human body cannot survive without. The human liver is continuously challenged with infectious organisms, alcohol and chemicals, congenital defects, autoimmunity and malignancy etc. LÄS MER
22. An insight into the metabolism of New Psychoactive Substances : Structural elucidation of urinary metabolites of synthetic cannabinoids and fentanyl analogues using synthesized reference standards
Sammanfattning : New Psychoactive Substances (NPS) is an umbrella term covering hundreds of substances across different drug groups. Many of these substances were originally developed for therapeutic use but have later appeared on the recreational drug market. LÄS MER
23. Genetics of diabetic subtypes
Sammanfattning : There are two major types of diabetes mellitus, Type 1 Diabetes (T1D) and Type 2 Diabetes (T2D), however a number of subtypes have been defined and classified. Maternally Inherited Diabetes and Deafness (MIDD) and Maturity Onset Diabetes of the Young (MODY) are monogenic forms, whereas Latent Autoimmune Diabetes in Adults (LADA) is thought to be a polygenic subtype similar to T1D. LÄS MER
24. Novel human in vitro systems for studies of drug inducted hepatotoxicity
Sammanfattning : Drug-induced liver injury (DILI) is a major human health concern, estimated to account for about half of all cases of acute liver failure in the general population. DILI also represents a significant problem in drug discovery, being one of the most common reasons for regulatory actions, including boxed warnings, restricted marketing and withdrawals of marketed drugs. LÄS MER
25. Proteomic and Functional Analysis of In Vitro Systems for Studies of Drug Disposition in the Human Small Intestine and Liver
Sammanfattning : To reach the bloodstream, an orally administered drug must be absorbed through the small intestine and avoid extensive clearance in the liver. Estimating these parameters in vitro is therefore important in drug discovery and development. LÄS MER