Sökning: "lipoxin"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet lipoxin.

  1. 1. The role of peridontitis and hepatocyte growth factor in systemic inflammation

    Författare :Johanna Lönn; Torbjörn Bengtsson; Fariba Nayeri; Anders Gustafsson; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatocyte growth factor; Porphyromonas gingivalis; periodontitis; systemic inflammation; coronary artery disease; chronic renal failure; lipoxin; Biomedicin; Biomedicine;

    Sammanfattning : An essential goal in addressing inflammation is the return of tissue to homeostasis. Persistent infections often cause prolonged response and accumulation of immune cells, inducing imbalance in pro- and anti-inflammatory mediators, tissue destruction, and chronic inflammation. LÄS MER

  3. 2. Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle

    Författare :Eva Wikström Jonsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cysteinyl leukotrienes; leukotriene receptor; histamine; antigen; smooth muscle; lipoxin; thromboxane; Schultz-Dale reaction;

    Sammanfattning : The cysteinyl leukotrienes (leukotriene C4, D4 and E4) have potent biological actions which significantly contribute to the airway obstruction in asthma. Several of these effects are blocked by drugs known as CysLT1-receptor antagonists, which have been introduced as new treatment for asthma. LÄS MER

  4. 3. Studies on the formation of leukotriene C4 and lipoxins from leukotriene A4 in human platelets

    Författare :Susanne Tornhamre; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human platelets lack 5-lipoxygenase activity, but possess enzymatic capacity to transform the unstable epoxide leukotriene (LT)A4 to the potent inflammatory agent LTC4 and lipoxins, a group of trihydroxylated tetraene-containing eicosanoids, which recently have been suggested to have an anti-inflammatory role. A novel pathway for the formation of lipoxin (LX)A4 via platelet lipoxygenation of SS,6R-diHETE and 5S,6S-diHETE, enzymatic/non-enzymatic hydrolysis products of LTA4, was discovered in human platelets. LÄS MER

  5. 4. Pro- and anti-inflammatory regulation of β2 integrin signalling in human neutrophils

    Författare :Veronika Brodin Patcha; Eva Särndahl; Emmanuelle Caron; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; inflammation; neutrophils; signalling; integrins; Cell biology; Cellbiologi;

    Sammanfattning : The body is under constant attack from pathogens trying to slip by our immune defence. If the barrier is breached, invading pathogens enter the tissues and cause inflammation. During this process neutrophils, constituting the first line of defence, leave the bloodstream and seek out and kill the invading pathogens. LÄS MER

  7. 5. Experimental studies of lipid mediator modulation of airway responsiveness

    Författare :Willem Abma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lipid mediators play an important role in responsiveness of the airways. The roles of prostanoids and leukotrienes in inducing airway inflammation and contraction are reasonably well established. LÄS MER