Sökning: "hepatocyte"

Visar resultat 11 - 15 av 83 avhandlingar innehållade ordet hepatocyte.

1. 11. Investigation of hepatocyte signaling pathways in chronic kidney disease : clinical and experimental studies

   Författare :Meng Li; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Chronic kidney disease (CKD) is defined as a loss of renal function from any cause and lasting for more than three months. The CKD phenotype is similar across multiple etiologies, suggesting that renal damage itself is a dominant factor. LÄS MER

3. 12. Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate in Tumor and Brain Development

   Författare :Martin Thelin; Matrixbiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; iduronic acid; chondroitin sulfate; esophagus squamous cell carcinoma; cancer; MET receptor; dermatan sulfate; hepatocyte growth factor; DS-epimerase 2; DS-epimerase 1;

   Sammanfattning : Cell behavior such as migration and proliferation, especially during cancer development, are balanced by the surrounding environment. Complex polysaccharides called glycosaminoglycans (GAGs) are part of this environment and they are known to modulate tumor development. LÄS MER

4. 13. Hormonal regulation of liver and tumor growth

   Författare :Ville Wallenius; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liver; cytokine; interleukin-6; tumor necrosis factor; primary liver growth promoter; cyproterone acetate; nafenopin; hepatocyte growth factor; HGF receptor; tumor; sarcoma; N-terminal; truncated;

   Sammanfattning : The aims of this thesis were to investigate the regulatory functions of interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) on liver growth, and the importance of hepatocyte growth factor (HGF) and the HGF receptor (Met) for growth of mesenchyme-derived tumors. The studies on different types of liver growth, measured as weight, DNA and protein content, and DNA synthesis, were performed on mice lacking the IL-6 or the TNF receptor-1 gene back-crossed to the C57bl/6 strain. LÄS MER

5. 14. Search for MODY and Type 2 diabetes genes

   Författare :Markku Lehto; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; mutation; MODY; mitochondrial DNA; MIDD; insulin deficiency; hepatocyte nuclear factor; Gestational diabetes; glucokinase; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : Diabetes is a heterogeneous disease influenced by both environmental and genetic factors. Maturity-onset diabetes of the young (MODY) is considered as a subform of Type 2 diabetes, which is inherited in an autosomal dominant fashion and expressed at childhood or early adult life. LÄS MER

7. 15. New Roles of Filamins in Cell Signaling, Transcription and Organ Development

   Författare :Xianghua Zhou; Göteborgs universitet; []
   Nyckelord :filamins; cell movement; hypoxia-inducible factor 1; proto-oncogene proteins c-met; mice; knockout; F-actin-binding proteins; integrins; GTB phosphohydrolases; genetic diseases; inborn; vascular endothelial cell growth factor A; Smad2 protein; hepatocyte growth factor; cartilage; osteogenesis; neovascularization; neoplasm metastasis;

   Sammanfattning : Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin networks and link them to cellular membranes. They integrate cell architectural and signaling functions and are essential for cell locomotion and development. LÄS MER