Sökning: "graft rejection."

Visar resultat 21 - 25 av 78 avhandlingar innehållade orden graft rejection..

1. 21. Allogeneic stem cell transplantation in children : identification and prevention of complications : adoptive transfer of EBV-immunity

   Författare :Åsa Gustafsson Jernberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Children; CTL; EBV; Graft-versus-leukaemia; Stemcell transplantation; unrelated;

   Sammanfattning : Allogeneic stem cell transplantation (SCT) can cure leukaemia, aplastic anaemia, and some inborn errors of metabolism and immunodeficiencies in children. As only 113 of patients who need SCT have an HLA-identical sibling, the use of alternative donors has increased, to over 50% of all paediatric SCTs at our centre. LÄS MER

3. 22. NK cell recognition : adaptability to host factors in normal and diabetic mice

   Författare :Sofia Johansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Natural Killer; NK cell; education; Non obese diabetic; NOD; diabetes; activation; graft; rejection; in vivo; method; receptor; repertoire;

   Sammanfattning : The overall aim of this thesis was to understand the rules, which guide NK cell behavior in vivo. NK cells are part of the innate immune system and are important in defense against certain virus infections and tumorigenic cells. They also play a role in rejecting bone marrow grafts. LÄS MER

4. 23. Alloreactivity in stem cell transplantation

   Författare :Anna Nordlander; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Acute graft-versus-host disease (GVHD), relapse and graft rejection are the main complications after allogeneic hematopoietic stem cell transplantation (HSCT). The aim of this thesis was to achieve a better understanding of the alloreactivity seen after HSCT, focusing on graft rejection, but also including the graft-versus-leukemia (GVL) effect and GVHD. LÄS MER

5. 24. Immunosuppresive properties of new potential drugs in transplantation

   Författare :Clara Paul; Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Transplantation of vital organs is today a widely used treatment when failure of the organ is a fact. To prevent rejection immunosuppresive treatment must be maintained lifelong, unless transplantation is perfomed between identical twins. LÄS MER

7. 25. Experimental modulation and suppression of anti-allograft immune response

   Författare :Öyvind Östraat; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; linomide; leflunomide; cyclophosphamide; mycophenolate mofetil; azathioprine; thalidomide; cyclosporin A; ciprofloxacin; flow cytometry; production; IL-2; Rat cardiac transplantation; allograft; Immunology; serology; transplantation; Immunologi; serologi;

   Sammanfattning : Abstract The objective of this investigation was to characterise the immunomodulatory or immunosuppressive effects of single drug treatment and the potential synergistic or additive effects of combined treatment with the focus on ciprofloxacin, thalidomide, mycophenolate mofetil, azathioprine, cyclophosphamide or leflunomide added to cyclosporin A (CyA). A rat cardiac transplant model was used to study graft survival and the influence on lymphocytes was evaluated by in vitro tests. LÄS MER