Sökning: "glucose signaling"

Visar resultat 26 - 30 av 202 avhandlingar innehållade orden glucose signaling.

  1. 26. Oscillatory Signaling and Insulin Secretion from Single ß-cells

    Författare :Olof Idevall Hagren; Anders Tengholm; Erik Gylfe; Leslie Satin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; Ca2 ; oscillations; beta-cell; insulin secretion; evanescent wave microscopy; PIP3; PKA; Epac; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : cAMP and Ca2+ are key regulators of exocytosis in many cells, including insulin-secreting pancreatic β-cells. Glucose-stimulated insulin secretion from β-cells is pulsatile and driven by oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), but little is known about the kinetics of cAMP signaling and the mechanisms of cAMP action. LÄS MER

  3. 27. Estrogen signaling in metabolic disease : a functional genomics approach

    Författare :Hui Gao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :estrogen receptor; insulin sensitivity; functional genomics; mouse liver; lipid metabolism;

    Sammanfattning : Estrogens have traditionally been associated with female reproduction. More and more evidence has also linked estrogens to maintenance of glucose homeostasis and normal heart function. LÄS MER

  4. 28. Mechanisms of insulin signaling and the role of caveolae

    Författare :Santiago Parpal; Pam Fredman; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Insulin regulates metabolic as well as mitogenic processes in target cells, involving a large number of mediators of signal transduction. In its role as a growth factor, insulin stimulates cell growth, in a process we demonstrate requires the participation of the Raf-1 kinase. LÄS MER

  5. 29. Calcium signaling in astroglial cells. Noradrenergic effects and regulation

    Författare :Håkan Muyderman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Astrocytes; Neurons; Noradrenaline; Glutamate; Fluorometry; Fura-2; Fluo-3; PBFI; Digital imaging; Voltage-patch-clamp; Whole-cell currents; Calcium; Potassium; Intercellular communication; Glutamate release; Neuron-glial interactions.;

    Sammanfattning : Astroglial cells are the most common cell type in the central nervous system and express a wide array of ion channels and neurotransmitter receptors. The cells organize into multicellular networks and exhibit a calcium-based excitability in which receptor-mediated calcium elevations propagate as intercellular waves over considerable distances. LÄS MER

  7. 30. Effect of hyperglycemia on glucose transport and intracellular signal transduction in skeletal muscle

    Författare :Yuichi Kawano; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :skeletal muscle; glucose transport; insulin signaling; hyperglycemia; PKC; Akt kinase; GotoKakizaki rat; phlorizin; muscle fiber type;

    Sammanfattning : Recent studies revealing the components of insulin signal transduction have raised the question of whether the defects in insulin signaling account for disturbed glucose metabolism in people with NIDDM. The major focus of this thesis is to elucidate the role of insulin signal transduction in the development of peripheral insulin resistance. LÄS MER