Avancerad sökning
Visar resultat 1 - 5 av 202 avhandlingar som matchar ovanstående sökkriterier.
1. Adrenergic signaling in insulin-sensitive tissues
Sammanfattning : Glucose metabolism in insulin-sensitive tissues such as skeletal muscle and adipose tissue is tightly regulated by external stimuli. Metabolic changes in these tissues have direct effects on whole body metabolism. Such metabolic changes can be induced or influenced by adrenergic stimulation. LÄS MER
2. Fat cell insulin resistance : an experimental study focusing on molecular mechanisms in type 2 diabetes
Sammanfattning : The aim of the present thesis was to further increase our understanding of mechanisms contributing to and maintaining cellular insulin resistance in type 2 diabetes (T2D). For this reason, the effects of high glucose and insulin levels on glucose transport capacity and insulin signaling, with emphasis on insulin receptor substrate 1 (IRS-1) were assessed in fat cells. LÄS MER
3. Oscillatory Ca2+ signaling in glucose-stimulated murine pancreatic β-cells : Modulation by amino acids, glucagon, caffeine and ryanodine
Sammanfattning : Oscillations in cytoplasmic Ca2+ concentration ([Ca2+]i) is the key signal in glucose-stimulated β-cells governing pulsatile insulin release. The glucose response of mouse β-cells is often manifested as slow oscillations and rapid transients of [Ca2+] i. LÄS MER
4. Towards a comprehensive modeling framework for studying glucose repression in yeast
Sammanfattning : The yeast Saccharomyces cerevisiae is an important model organism for human health and for industry applications as a cell factory. For both purposes, it has been an important organism for studying glucose repression. LÄS MER
5. Regulation of intracellular signaling events that modulate insulin action
Sammanfattning : Insulin regulates several mechanisms of fundamental importance to the body involving glucose, fat andprotein metabolism. Insulin resistance in skeletal muscle, liver and adipose tissue promotes an increaseddemand for insulin secretion. LÄS MER