Sökning: "genome stability"
Visar resultat 1 - 5 av 113 avhandlingar innehållade orden genome stability.
1. Guardians of the genome : Connecting chromatin structure and genome integrity in Saccharomyces cerevisiae
Sammanfattning : Branched DNA structures arise during recombination and during other DNA repair processes such as repair of stalled replication forks. One branched structure, the Holliday Junction (HJ), is a four-way junction that can connect sister chromatids or homologous chromosomes. We show a physical interaction between the HJ-cleaving enzyme Yen1 and Uls1. LÄS MER
2. Chromosome-specific adaptations of RNA stability and the roles of the roX RNAs in dosage compensation
Sammanfattning : Sex chromosomes evolved from an ancient pair of autosomes and the Y chromosome lost most of its genetic information in the process. This created two kinds of genomic imbalances: the first one between males (XY) and females (XX) and the second one between the sex chromosomes and the autosomes (X:AA). LÄS MER
3. Systems-level characterization of probiotic bifidobacteria - Towards rational optimization of industrial production
Sammanfattning : Probiotic Bifidobacterium strains contribute to a healthy gut microbiota of their hosts. Increasing public awareness of this positive effect has resulted in a growing demand for these microorganisms. LÄS MER
4. The Smc5/6 complex : the mysterious guardian of genome stability
Sammanfattning : An intricate network of proteins ensures the faithful transmission of genetic information through cell generations. The Structural Maintenance of Chromosomes (SMC) protein complex family plays a pivotal role in maintaining genome stability. LÄS MER
5. Regulation of ribonucleotide reductase and the role of dNTP pools in genomic stability in yeast Saccharomyces cerevisiae
Sammanfattning : Every living organism is programmed to reproduce and to pass genetic information to descendants. The information has to be carefully copied and accurately transferred to the next generation. Therefore organisms have developed the network of conserved mechanisms to survey the protection and precise transfer of the genetic information. LÄS MER