Sökning: "genome stability"

Visar resultat 6 - 10 av 113 avhandlingar innehållade orden genome stability.

  1. 6. Chromatin remodeling and dna topology in transcription and genome stability

    Författare :Jenna Persson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Eukaryotic DNA is wrapped around histone proteins to form nucleosomes, the fundamental repeating unit of chromatin. DNA packaging into chromatin both solves and creates problems. It allows the centimeters, or even meters, of DNA that constitute a eukaryotic genome to fit inside a micrometer-scale cell nucleus. LÄS MER

  3. 7. Mitotic failure and genome stability in benign, premalignant and malignant human tissues

    Författare :Rüdiger G Steinbeck; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :aneuploidy; CDF; clonal selection; DNA content; image microphotometry; interphase; microsection; nondisjunction; unbalanced telophase;

    Sammanfattning : Mitotic failure may occur throughout the human lifespan. Individual nuclear mistakes will escape detection within the mass of somatic cells. The probability of nondetection increases with progression in development. LÄS MER

  4. 8. Genome Evolution in Maternally Inherited Insect Endosymbionts

    Författare :Lisa Klasson; Siv Andersson; Jonas Sandström; George Weinstock; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Biology; Biologi;

    Sammanfattning : Symbiosis is a widely common phenomenon in nature and has undoubtedly contributed to the evolution of all organisms on earth. Symbiotic associations can be of varying character, such as parasitic or mutualistic, but all imply a close relationship. LÄS MER

  5. 9. The role of the cohesin loader in genome stability : a journey from yeast to human

    Författare :Fosco Giordano; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Structural Maintenance of Chromosome (SMC) complexes, as their name suggests, have a central role in maintaining the higher structure of genomes, from bacteria to human, and in doing so protecting their integrity. Cohesin, one of three SMC complexes, is required to hold sister chromatids together until anaphase, and for homologous recombination-based DNA repair. LÄS MER

  7. 10. Utilization of single-cell RNA-Seq and genome-scale modeling for investigating cancer metabolism

    Författare :Johan Gustafsson; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genome-scale metabolic modeling; cancer; metabolism; single-cell RNA-Seq;

    Sammanfattning : Cancer remains a leading cause of death worldwide, and its dysregulated metabolism is a promising target for therapy. However, metabolism is complex to study – the metabolism of a cell involves the interplay of thousands of chemical reactions that are combined in different ways across tissues and cell types. LÄS MER