Sökning: "genome reduction"

Visar resultat 11 - 15 av 83 avhandlingar innehållade orden genome reduction.

  1. 11. Molecular Evolution of the Vertebrate Genome

    Författare :Kiwoong Nam; Hans Ellegren; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : In this thesis, I studied molecular evolution of the vertebrate genome, focusing on sex chromosomes, protein coding genes, and genome size variation. The evolutionary history of avian sex chromosomes was analyzed by comparing substitution rate among 12 gametologous gene pairs on the Z and W chromosomes. LÄS MER

  3. 12. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation

    Författare :Alba Atienza Párraga; Helena Jernberg-Wiklund; Fredrik Öberg; Antonia Kalushkova; Miguel Angel Peinado; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Multiple myeloma; epigenetics; Polycomb; EZH2; miRNA; DNA methylation; inhibitor.; Experimentell patologi; Experimental Pathology;

    Sammanfattning : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. LÄS MER

  4. 13. Colorectal cancer : genome, transcriptone and proteome dynamics

    Författare :Jens Karsten Habermann; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Colorectal carcinomas are the third most common malignancies in the Western World. Despite screening programs about 70% of these tumors are detected at advanced stages. Late diagnosis, however, results in a significant reduction of average survival times. LÄS MER

  5. 14. Polyploid Phylogenetics in Plants: Insights on non-model organisms in Fabaceae and Malvaceae

    Författare :Jonna S. Eriksson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Diploidization; genome duplication; haplotypes; Hibisceae; Hibiscus; homoeologues; high-throughput sequencing; Pavonia; Malvaceae; polyploidization;

    Sammanfattning : Genome duplication is a common phenomenon in angiosperms and advances in sequencing technologies and bioinformatics is now revealing its prevalence and significance. In a polyploidization event all genes in a genome are doubled. LÄS MER

  7. 15. Statistical Feature Selection : With Applications in Life Science

    Författare :Roland Nilsson; Jesper Tegnér; Johan Björkegren; Sepp Hochreiter; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Machine learning; supervised learning; classification; dimemsionality reduction; multiple testing; gene expression; microarray; cancer; Bioinformatics; Bioinformatik;

    Sammanfattning : The sequencing of the human genome has changed life science research in many ways. Novel measurement technologies such as microarray expression analysis, genome-wide SNP typing and mass spectrometry are now producing experimental data of extremely high dimensions. LÄS MER