Sökning: "Antonia Kalushkova"

Hittade 3 avhandlingar innehållade orden Antonia Kalushkova.

  1. 1. Epigenetic gene regulation in multiple myeloma and mood disorders

    Författare :Antonia Kalushkova; Fredrik Öberg; Helena Jernberg-Wiklund; Lucia Cavelier; Anthony Wright; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IKKα; retinoic acid receptor; multiple myeloma; Polycomb; Ouabain; mood disorders;

    Sammanfattning : Epigenetics continues to be redefined and new discoveries are likely to revolutionise the field still further. This thesis explores different aspects of how epigenetic regulation of gene expression contributes to human disease. LÄS MER

  3. 2. Targeting molecular mechanisms for epigenetic silencing in multiple myeloma : Implications for biology and precision medicine

    Författare :Patrick Nylund; Helena Jernberg Wiklund; Antonia Kalushkova Nair; Fredrik Öberg; Toril Holien; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; epigenetics; PRC2; lncRNA; metabolomics; miRNA.;

    Sammanfattning : Multiple myeloma (MM) is a heterogeneous haematological cancer where malignant plasma cells clonally expand within the bone marrow. The transcriptional repressor PRC2 and its catalytic subunit EZH2 play a major role in MM, as PRC2 re-targeting results in a MM-specific gene silencing profile. LÄS MER

  4. 3. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation

    Författare :Alba Atienza Párraga; Helena Jernberg-Wiklund; Fredrik Öberg; Antonia Kalushkova; Miguel Angel Peinado; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Multiple myeloma; epigenetics; Polycomb; EZH2; miRNA; DNA methylation; inhibitor.; Experimentell patologi; Experimental Pathology;

    Sammanfattning : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. LÄS MER