Sökning: "Miguel Angel Peinado"

Hittade 1 avhandling innehållade orden Miguel Angel Peinado.

  1. 1. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation

    Författare :Alba Atienza Párraga; Helena Jernberg-Wiklund; Fredrik Öberg; Antonia Kalushkova; Miguel Angel Peinado; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; epigenetics; Polycomb; EZH2; miRNA; DNA methylation; inhibitor.; Experimentell patologi; Experimental Pathology;

    Sammanfattning : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. LÄS MER