Sökning: "göran uppsala medicine"

Visar resultat 1 - 5 av 144 avhandlingar innehållade orden göran uppsala medicine.

  1. 1. Novel and refined small-scale approaches to determine the intrinsic dissolution rate of drugs

    Författare :Sara B. E. Andersson; Göran Alderborn; Göran Frenning; Peter Langguth; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dissolution; intrinsic dissolution rate; poorly water-soluble compounds; single particle dissolution; solubility; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Many drugs are administered as crystalline particles compressed into tablets and taken orally. When the tablet reaches the gastrointestinal tract, it disintegrates and the drug particles dissolve in the gastrointestinal fluid. The dissolved molecules are absorbed across the intestinal membranes into the bloodstream to reach their target sites. LÄS MER

  3. 2. Confined Compression of Single Particles : Development of a Novel Triaxial Testing Instrument and Particle-Scale Modelling

    Författare :Henrik Jonsson; Göran Frenning; Göran Alderborn; Abderrahim Michrafy; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Powder compaction; Compression; Single particle; Particle mechanics; Powder mechanics; Confined conditions; Triaxial; Apparatus design; Modelling; Galenisk farmaci; Pharmaceutics;

    Sammanfattning : When predicting the performance of a powder compaction process, assessing the behaviour of the particles comprising the powder bed is of central relevance. Currently, however, no experimental methods are available for mimicking the multiaxial loading conditions imposed on the individual particles in a powder bed during compaction, and such analyses are therefore usually performed in silico. LÄS MER

  4. 3. Flow and Compression of Granulated Powders : The Accuracy of Discrete Element Simulations and Assessment of Tablet Microstructure

    Författare :Ann-Sofie Persson; Göran Frenning; Göran Alderborn; Marie Wahlgren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Discrete Element Method; Granule; Flow; Angle of Repose; Discharge Rate; Shear; Rolling friction; Compression; Elastic deformation; Microstructure; Degree of compression; Tensile strength; Galenisk farmaci; Pharmaceutics;

    Sammanfattning : Simulations are powerful and important tools for gaining insight into powder processes. Ultimately, simulations have the potential to replace experiments. Thus, accurate models and insight into the essential factors for descriptions of powder behaviour are required. LÄS MER

  5. 4. Regional Lung Mechanics and Influence of an Active Diaphragm in Experimental Lung Injury

    Författare :Mariangela Pellegrini; Anders Sune Larsson; Göran Hedenstierna; Michael Quintel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute respiratory distress syndrome; artificial respiration; diaphragm; pulmonary atelectasis; lung imaging; respiratory system; animal model; Fysiologi; Physiology; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

    Sammanfattning : Despite being an essential life-support strategy in severe respiratory failure, mechanical ventilation can, if not optimally set and monitored, lead to injury of the lung parenchyma and diaphragm. These conditions are called ventilator-induced lung injury and ventilator-induced diaphragmatic dysfunction (VIDD), respectively. LÄS MER

  7. 5. Powder mechanics and dispersion properties of adhesive mixtures for dry powder inhalers : Conceptualized as a blend state model

    Författare :Jonas Rudén; Göran Alderborn; Göran Frenning; Tobias Bramer; Kyrre Thalberg; Regina Scherliess; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inhalation; Dry Powder Inhaler; adhesive mixture; aerosols; powder mechanics; dispersibility; aerosolization; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Inhaled medicines is a therapy that dates back several thousands of years. Nowadays, using various types of inhaler devices to deliver active pharmaceutical ingredients (APIs) to treat respiratory diseases has become common practice. LÄS MER