Sökning: "excess function"

Visar resultat 16 - 20 av 191 avhandlingar innehållade orden excess function.

1. 16. A new family of survival functions and a method for measuring risk inequalities

   Författare :Harald Hannerz; Statistiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mortality law; survival analysis; risk inequalities; excess fraction; Mortality law; survival analysis; risk inequalities; excess fraction;

   Sammanfattning : The present compilation thesis is divided into two sections, one for each of two separate methodological issues: reduction of random errors in mortality estimates and offsetting random variation related bias in data generated estimators of risk inequalities. Summary of section A In regard to the first issue a new family of survival functions is proposed. LÄS MER

3. 17. Polycystic ovary syndrome – Studies of metabolic and ovarian disturbances and effects of physical exercise and electro-acupuncture

   Författare :Louise Mannerås Holm; Göteborgs universitet; []
   Nyckelord :adipocyte size; adipose tissue; androgen excess; animal models; body composition; electro-acupuncture; insulin resistance; ovary; physical exercise; polycystic ovary syndrome;

   Sammanfattning : Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in premenopausal women. The syndrome is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian (PCO) morphology. Metabolic disturbances, such as insulin resistance and obesity, are also associated with PCOS. LÄS MER

4. 18. Studies on fat cell function in human obesity and insulin resistance

   Författare :Patrik Löfgren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Fat cell; lipolysis; lipogenesis; leptin; obesity; perilipin; polymorphism; post-obese; TNF-alpha; weightreduction.;

   Sammanfattning : Enlarged fat cells, due to excess tri-glyceride (TG) stores with increased basal lipolysis (TG breakdown) and blunted action of the major regulatory hormones of fat cell metabolism (catecholamines and insulin) are hallmarks of common obesity in humans. It is, however, not known whether these aberrations are caused by obesity per se or is a consequence of obesity. LÄS MER

5. 19. Metabolic and endocrine function of human adipose tissue with focus on regional differences

   Författare :Vanessa van Harmelen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :acylation stimulating protein; adipocytes; adipose tissue heterogeneity; adrenoceptors; insulin; leptin; lipogenesis; lipolysis; noradrenaline; plasminogen activator inhibitor-1; preadipocytes; tumour necrosis factor-cc;

   Sammanfattning : The major function of human adipose tissue is to store excess ingested energy and to release free fatty acids after hydrolysis of triglycerides (lipolysis), to meet the energy demands of other organs. Adipose tissue also has a secretory function. LÄS MER

7. 20. Mitochondrial function in human skeletal muscle: with special reference to exercise and training

   Författare :Michail Tonkonogi; Högskolan Dalarna; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :aerobic metabolism; oxidative phosphorylation; mitochondria; oxygen utilisation; citrate synthase; ADP sensitivity; ATP; muscle fibres; hydrogen ions; lactate; free radicals; proton leak; uncoupling; exercise; aerobic metabolism; oxidative phosphorylation; mitochondria; oxygen utilisation; citrate synthase; ADP sensitivity; ATP; muscle fibres; hydrogen ions; lactate; free radicals; proton leak; uncoupling; exercise;

   Sammanfattning : The overall objective of this thesis was to study the adaptation of oxidative function in human skeletal muscle to acute exercise of different modes, intensities and durations, and to endurance training. The effects of endurance training on mitochondrial function were evaluated in cross-sectional and longitudinal studies by measurements of mitochondrial oxygen consumption in isolated mitochondria and permeabilised muscle fibres and measurements of mitochondrial ATP production rate in isolated mitochondria. LÄS MER