Sökning: "adipocyte size"

Visar resultat 1 - 5 av 39 avhandlingar innehållade orden adipocyte size.

  1. 1. Human adipose tissue morphology and function : relation to insulin sensitivity and glucose tolerance with focus on pregnancy and women with previous gestational diabetes mellitus

    Författare :Henrik Svensson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipose tissue; Adipocyte; Adipokines; Insulin resistance; Pregnancy; Gestational diabetes mellitus; Type 2 diabetes;

    Sammanfattning : Obesity is a global health problem and affects women of reproductive age. During pregnancy, obesity increases the risk for gestational diabetes mellitus (GDM), in turn predisposing for type 2 diabetes (T2D). LÄS MER

  3. 2. Monoglyceride Lipase and Hormone-Sensitive Lipase - Molecular and structural aspects

    Författare :Marie Karlsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; genomic organisation; baculovirus-insect cells; catalytic triad; alfa beta hydrolase fold; tissue distribution; cDNA sequence; lipolysis; adipocyte; monoglyceride lipase; hormone-sensitive lipase; chromosomal localisation; Clinical biology; Klinisk biologi;

    Sammanfattning : Triglycerides in the adipocyte are hydrolysed by means of three consecutive reactions through the combined action of two lipases: hormone-sensitive lipase (HSL) and monoglyceride lipase (MGL). HSL catalyses the first and rate-limiting step, i.e. LÄS MER

  4. 3. Glucose and lipid metabolism in insulin resistance : an experimental study in fat cells

    Författare :Jonas Burén; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Public health; adipocyte; insulin resistance; type 2 diabetes; insulin signalling; glucose uptake; insulin; glucose; dexamethasone; insulin receptor substrate; protein kinase B; GLUT4; lipoprotein lipase; Folkhälsomedicin; Public health medicine research areas; Folkhälsomedicinska forskningsområden; medicin; Medicine;

    Sammanfattning : Type 2 diabetes is usually caused by a combination of pancreatic β-cell failure and insulin resistance in target tissues like liver, muscle and fat. Insulin resistance is characterised by an impaired effect of insulin to reduce hepatic glucose production and to promote glucose uptake in peripheral tissues. LÄS MER

  5. 4. Polycystic ovary syndrome – Studies of metabolic and ovarian disturbances and effects of physical exercise and electro-acupuncture

    Författare :Louise Mannerås Holm; Göteborgs universitet; []
    Nyckelord :adipocyte size; adipose tissue; androgen excess; animal models; body composition; electro-acupuncture; insulin resistance; ovary; physical exercise; polycystic ovary syndrome;

    Sammanfattning : Polycystic ovary syndrome (PCOS) is the most common endocrine abnormality in premenopausal women. The syndrome is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian (PCO) morphology. Metabolic disturbances, such as insulin resistance and obesity, are also associated with PCOS. LÄS MER

  7. 5. Adipocyte size and function in the epididymal and inguinal fat depots

    Författare :Claes Fryklund; Glukostransport och proteintrafficking; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Adipocytes; Inguinal fat; Epididymal fat; Insulin resistance; Hypertrophy; Hyperplasia;

    Sammanfattning : Nearly 60% of the worlds adult population is projected to be overweight or obese by 2030. The prevalence of obesity- related diseases, such as type 2 diabetes (T2D), has increased markedly in the past decades. The adipose tissue plays an important role in disease progression of T2D. LÄS MER